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Abivax Completes First-In-Man Study of HIV Treatment

By R&D Editors | December 1, 2014

Abivax, a leading clinical stage biotech company developing and commercialising anti-viral compounds and human vaccines, announced the successful completion of its Phase 1 first-in-man study of ABX464, which has been designed to potentially deliver a number of important clinical benefits when treating patients with HIV.
 
AXB464 is a novel, small molecule with the potential to inhibit HIV replication. Through its unique mode of action, ABX464 is the first anti-HIV drug able to induce a long-lasting HIV viral load reduction even after treatment has been stopped, in pre-clinical testing in mice. ABX464 has also shown an absence of resistance in vitro.
 
ABX464 is the first candidate molecule coming from ABIVAX’s proprietary technology platform and chemical library, generated from its deep understanding of the processing of viral RNA within the human host cell and the ability of compounds from its novel library to inhibit RNA-protein interactions. This platform allows ABIVAX to potentially address a broad range of viral targets.
 
The successful first-in-man trial of ABX464 in healthy volunteers assessed pharmacokinetic properties and biological safety. The Phase 1 study was completed with single administration of 4 doses: 50, 100, 150 and 200mg, and saw no serious adverse event and no clinically significant abnormal result in physical examinations, laboratory test results, vital signs and ECG.
 
Abivax plans to start a Phase 2 study in patients with HIV in the coming months.
 
Source: Abivax
 
 

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