GE Healthcare Life Sciences has added an affinity resin to its portfolio of technologies for the purification of antibody-based fragments. The resin, LambdaFabSelect, is a designed tool for the GMP-regulated purification of antibodies and antibody fragments that contain a lambda light chain. Antibody fragments are receiving increased attention as potential future biopharmaceuticals because, compared with monoclonal antibodies, they have a number of advantages such as improved tissue penetration and the ability to bind to targets inaccessible to conventional antigen-binding sites.
The launch of LambdaFabSelect follows the success of KappaSelect an affinity resin developed in an earlier collaboration between BAC and GE Healthcare. KappaSelect is designed for the purification of antibodies and antibody fragments containing the kappa light chain.