Analysis of opioid prescription practices finds areas of concern
An analysis of national prescribing patterns shows that more than half
of patients who received an opioid prescription in 2009 had filled another
opioid prescription within the previous 30 days. This report also suggested
potential opportunities for intervention aimed at reducing abuse of prescription
Researchers from the National Institute on Drug Abuse (NIDA), a component
of the National Institutes of Health, will publish results of this analysis
in this week’s Journal of the American Medical Association (JAMA).
“More research is needed to see if current practices are working, with
a closer look at why so many patients are getting multiple prescriptions
within a short period of time,” said NIDA Director Nora D. Volkow, M.D. “As
a nation, it is important that we all become better informed about effective
pain management and the risks of abusing prescription painkillers.”
This analysis comes on the heels of a nearly 20 year increase in the use of prescription painkillers. From 1991 to 2009, prescriptions for opioid analgesics increased almost threefold, to over 200 million. According to the Drug Abuse Warning Network system, which monitors drug-related emergency department visits and drug-related deaths, emergency room visits related to the nonmedical use of pharmaceutical opioids has doubled between 2005 and 2009. While these medications are crucial for pain management, their wide availability may also result in leftover pills in family medicine cabinets, increasing opportunities for abuse, as well as a host of serious medical consequences, including addiction. Most abusers report getting these medications from friends and relatives who had been prescribed opioids, or they are abusing their own medications.
This study used data from SDI?s Vector One National database, a privately
owned national-level prescription and patient tracking service. The sample
included 79.5 million prescriptions dispensed in the United States during
2009, which represent almost 40 percent of all the opioid prescriptions
filled nationwide. They broke down the prescriptions by physician specialty,
patient’s age, duration of prescription, and whether or not the patient
had previously filled a prescription for an opioid analgesic within the
past 30 days. The researchers looked at prescribing practices for younger
patients, who are more at risk than older adults for opioid abuse and
The records show that approximately 56 percent of painkiller prescriptions
were given to patients who had filled another prescription for pain from
the same or different providers within the past month. In addition, nearly
12 percent of opioids prescribed were to young people aged 10-29. Most
of these were hydrocodone- and oxycodone-containing products, like Vicodin
and Oxycontin. Dentists were the main prescribers for youth aged 10-19
years old. Nearly 46 percent of opioid prescriptions were given to patients
between ages 40 and 59, and most of those were from primary care providers.
The current issue of JAMA also includes an accompanying commentary from
Dr. Volkow and Dr. Thomas McLellan of the University of Pennsylvania
School of Medicine. They point out that according to the Centers for
Disease Control and Prevention, prescription opioid overdose is now the
second leading cause of accidental death in the United States, killing
more people than heroin and cocaine combined. They also state that this
is compelling evidence for the need to develop smart strategies to curtail
abuse of opioid analgesics, without jeopardizing pain treatment.
The analysis can inform policy makers wanting to implement systems to
reduce opioid abuse. Already many states are looking at prescription
drug monitoring programs that will give physicians access to information
on prescriptions previously received by their patients.
The research letter and commentary
can be found online beginning April 6 at http://jama.ama-assn.org/.
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