Research & Development World

  • R&D World Home
  • Topics
    • Aerospace
    • Automotive
    • Biotech
    • Careers
    • Chemistry
    • Environment
    • Energy
    • Life Science
    • Material Science
    • R&D Management
    • Physics
  • Technology
    • 3D Printing
    • A.I./Robotics
    • Software
    • Battery Technology
    • Controlled Environments
      • Cleanrooms
      • Graphene
      • Lasers
      • Regulations/Standards
      • Sensors
    • Imaging
    • Nanotechnology
    • Scientific Computing
      • Big Data
      • HPC/Supercomputing
      • Informatics
      • Security
    • Semiconductors
  • R&D Market Pulse
  • R&D 100
    • Call for Nominations: The 2025 R&D 100 Awards
    • R&D 100 Awards Event
    • R&D 100 Submissions
    • Winner Archive
    • Explore the 2024 R&D 100 award winners and finalists
  • Resources
    • Research Reports
    • Digital Issues
    • R&D Index
    • Subscribe
    • Video
    • Webinars
  • Global Funding Forecast
  • Top Labs
  • Advertise
  • SUBSCRIBE

Bacteria Used to Carry Medicine

By R&D Editors | March 30, 2012

To the ranks of horses, donkeys, camels and other animals that have served humanity as pack animals or beasts of burden, scientists are now enlisting bacteria to ferry nano-medicine cargos throughout the human body. They reported on progress in developing these “backpacking” bacteria — so small that a million would fit on the head of a pin — at the 243rd National Meeting & Exposition of the American Chemical Society.

“Cargo-carrying bacteria may be an answer to a major roadblock in using nano-medicine to prevent, diagnose and treat disease,” David H. Gracias, Ph.D., leader of the research team said. Gracias explained that nanotechnology is the engineering of ultra-small machines and other devices. These devices generally lack practical self-sustaining motors to move particles of medication, sensors and other material to diseased parts of the body. So why not attach such cargo to bacteria, which have self-propulsion systems, and have them hike around the human body?

“Currently, it is hard to engineer microparticles or nanoparticles capable of self-propelled motion in well-defined trajectories under biologically relevant conditions,” Gracias said. He is with Johns Hopkins University in Baltimore, Maryland. “Bacteria can do this easily, and we have established that bacteria can carry cargo.”

In addition, bacteria can respond to specific biochemical signals in ways that make it possible to steer them to desired parts of the body. Once there, bacteria can settle down, deposit their cargo and grow naturally. Bacteria already live all over the body, particularly in the large intestine, with bacterial cells outnumbering human cells 10-to-1. Despite their popular reputation as disease-causers, there are bacteria in the human body, especially in the intestinal tract, that are not harmful, and the backpackers fall into that category.

Gracias’ bacteria don’t really carry little nylon or canvas backpacks. Their “backpacks” are micro- or nano-sized molecules or devices that have useful optical, electrical, magnetic, electrical or medicinal properties. The cargos that the team tested also varied in size, shape and material. So far, the team has loaded beads, nanowires and lithographically fabricated nanostructures onto bacteria.

Other scientists are seeking to enlist bacteria in transporting nano-cargo. They already have established, for instance, that large numbers of bacteria — so-called “bacterial carpets” — can move tiny objects. Gracias’ research focuses on attaching one piece of cargo to an individual bacterium, rather than many bacteria to much larger cargo. The bacteria, termed “biohybrid devices,” can still move freely, even with the cargo stuck to them.

“This is very early-stage exploratory research to try and enable new functionalities for medicine at the micro- and nanoscale by leveraging traits from bacteria,” explained Gracias. “Our next steps would be to test the feasibility of the backpacking bacteria for diagnosing and treating disease in laboratory experiments. If that proves possible, we would move on to tests in laboratory mice. This could take a few years to complete.”

Date: March 29, 2012
Source: American Chemical Society

Related Articles Read More >

Eli Lilly facility
9 R&D developments this week: Lilly builds major R&D center, Stratolaunch tests hypersonic craft, IBM chief urges AI R&D funding
professional photo of wooly mammoth in nature --ar 2:1 --personalize sq85hce --v 6.1 Job ID: 47185eaa-b213-4624-8bee-44f9e882feaa
Why science ethicists are sounding skepticism and alarm on ‘de-extinction’
ALAFIA system speeds complex molecular simulations for University of Miami drug research
3d rendered illustration of the anatomy of a cancer cell
Funding flows to obesity, oncology and immunology: 2024 sales data show where science is paying off
rd newsletter
EXPAND YOUR KNOWLEDGE AND STAY CONNECTED
Get the latest info on technologies, trends, and strategies in Research & Development.
RD 25 Power Index

R&D World Digital Issues

Fall 2024 issue

Browse the most current issue of R&D World and back issues in an easy to use high quality format. Clip, share and download with the leading R&D magazine today.

Research & Development World
  • Subscribe to R&D World Magazine
  • Enews Sign Up
  • Contact Us
  • About Us
  • Drug Discovery & Development
  • Pharmaceutical Processing
  • Global Funding Forecast

Copyright © 2025 WTWH Media LLC. All Rights Reserved. The material on this site may not be reproduced, distributed, transmitted, cached or otherwise used, except with the prior written permission of WTWH Media
Privacy Policy | Advertising | About Us

Search R&D World

  • R&D World Home
  • Topics
    • Aerospace
    • Automotive
    • Biotech
    • Careers
    • Chemistry
    • Environment
    • Energy
    • Life Science
    • Material Science
    • R&D Management
    • Physics
  • Technology
    • 3D Printing
    • A.I./Robotics
    • Software
    • Battery Technology
    • Controlled Environments
      • Cleanrooms
      • Graphene
      • Lasers
      • Regulations/Standards
      • Sensors
    • Imaging
    • Nanotechnology
    • Scientific Computing
      • Big Data
      • HPC/Supercomputing
      • Informatics
      • Security
    • Semiconductors
  • R&D Market Pulse
  • R&D 100
    • Call for Nominations: The 2025 R&D 100 Awards
    • R&D 100 Awards Event
    • R&D 100 Submissions
    • Winner Archive
    • Explore the 2024 R&D 100 award winners and finalists
  • Resources
    • Research Reports
    • Digital Issues
    • R&D Index
    • Subscribe
    • Video
    • Webinars
  • Global Funding Forecast
  • Top Labs
  • Advertise
  • SUBSCRIBE