Cisbio Bioassays launched Tag-lite, its new cellular platform for cell surface receptor study and screening, at the Society for Biomolecular Sciences Conference & Exhibition in Lille, France. Tag-lite is a homogeneous, non-radioactive alternative for the study of cell surface receptor dimerization and ligand binding.
Tag-lite combines two technologies, HTRF, Cisbio Bioassays’ technology for the detection of molecular interactions in vitro, and SNAP-tag, Covalys Biosciences’ self-labeling protein tag system. Tag-lite offers a comprehensive reagent and method selection for the investigation of G-protein coupled receptor (GPCR) binding and mechanistics, and preserves the functionality of the receptor and the intracellular signaling pathway.
Tag-lite is a non-radioactive cell-based platform that can be used in binding, dimerization, and different assays, all while eliminating the high costs associated with radioactive waste and related materials.
The study of ligand binding and dimerization is an important part of drug discovery research. Ligand binding study, in particular, has traditionally been a research area that relies on radioactive methods. Like radioactivity, the Tag-lite labelling concept does not impair ligand binding capability and therefore provides the same pharmacological relevance as reference methods.
The Tag-lite system comprises a series of reagents and will also be offered as part of Cisbio Bioassays’ custom-labelled ligand and custom plasmid, cell line, and assay design services.
