Hollow fiber bioreactor cartridges from FiberCell Systems Inc. offer a simple two-compartment set-up for in vitro toxicology with higher levels of reproducible control of complex growth, infection, treatment, and sampling regimens. This system permits a highly realistic simulation of in vivo drug effects in a dynamically controlled system providing data that more accurately reflects biological responses to pharmacokinetics and pharmacodynamics than other methods. The model can be used with antibiotics, anti-viral agents and anti-cancer drugs. The design is fully disposable and will take into account the potential use of weaponized pathogens and genetically modified organisms.
Advantages of FiberCell Systems bioreactors:
1) Closed bio-safe system
2) Organism load can be high to match human infections and uncover the emergence of drug resistance.
3) Drug pharmacokinetics can be exactly modeled on human profile.
4) Multiple experiments can be run simultaneously.
5) Complex systems such as two drug or two cell type cultures can be easily set up.