High-performance liquid chromatography (HPLC) is the most widely used method for monitoring industrial-scale fermentation. But HPLC requires a lot of time, a high degree of skill, and can be expensive in the long-term. In addition, it can only analyze soluble components. Near-infrared (NIR) spectrometry, as detailed in a Bruker Optics white paper, can perform the same analysis with no waste and much greater speed.
