BioFocus DPI launched six new biologically targeted libraries of novel, drug-like compounds that specifically target ion channels, kinases, and proteases.
The new SoftFocus ion channel library (SFI13) has been designed using BioFocus DPI’s Helical Domain Recognition Analysis (HDRA) approach, which links X-ray, sequence alignment, and SAR data. HDRA is used to rationalize scaffold binding in the pore regions of ion channels and to guide monomer selection.
BioFocus DPI’s four new SoftFocus kinase libraries (SFK54, SFK55, SFK56 and SFK57) have been developed to target hinge, DFG-out, and novel binding modes. The SFK collection has been independently determined to have the greatest population of kinase-like molecules available for screening.
BioFocus DPI’s new SoftFocus protease library (SFP03) targets cysteine and serine proteases and is designed using a new technique which is based upon structures of more than 50 protease-ligand complexes available from the Protein Data Bank.