Research & Development World

  • Home Page
  • Topics
    • Aerospace
    • Archeology
    • Automotive
    • Biotech
    • Chemistry
    • COVID-19
    • Environment
    • Energy
    • Life Science
    • Material Science
    • R&D Market Pulse
    • R&D Management
    • Physics
  • Technology
    • 3D Printing
    • A.I./Robotics
    • Battery Technology
    • Controlled Environments
      • Cleanrooms
      • Graphene
      • Lasers
      • Regulations/Standards
      • Sensors
    • Imaging
    • Nanotechnology
    • Scientific Computing
      • Big Data
      • HPC/Supercomputing
      • Informatics
      • Security
      • Software
    • Semiconductors
  • 2021 R&D 100 Award Winners
    • R&D 100 Awards
    • 2020 Winners
    • Winner Archive
  • Resources
    • Digital Issues
    • Podcasts
    • Subscribe
  • Global Funding Forecast
  • Webinars

Computational Model provides New Insights into HIV-1 Vaccine Design

By R&D Editors | September 18, 2015

An HIV virus attacking a T cellLOS ALAMOS, NM — Scientists at Los Alamos National Laboratory have created a computational model that could change the way that researchers look at possibilities for an HIV-1 vaccine.

“An effective HIV-1 vaccine has proven elusive, partly due to the difficulty of causing an immune response that can neutralize the diverse viral strains circulating in the human population,” said Alan Perelson, of Los Alamos’ Theoretical Biology and Biophysics group. “Harnessing the power of broadly neutralizing antibodies, which emerge years into a chronic HIV infection, could help overcome this challenge.”

Shishi Luo and Perelson, published their findings in the paper “Competitive exclusion by autologous antibodies can prevent broad HIV-1 antibodies from arising.”

They used a mathematical model to examine how broadly neutralizing antibodies coevolve with HIV. By simulating the co-evolution of multiple viral strains and antibody populations, Perelson and Luo show that broadly neutralizing antibodies emerge late in infection due to competition from the highly specific antibody response to the dominant viral species in an infected person.

In their model, broadly neutralizing antibodies emerge earlier, and face less competition, in infections caused by multiple distinct strains of HIV compared with single strains. The findings support the view that a vaccine containing a mixture of diverse viral strains might reduce this competition, reduce the number of antibody mutations and elicit broadly neutralizing antibodies earlier in infection.

Traditional vaccine design is based on the premise that infection is protective and that a vaccine should mimic a natural infection. However, Luo and Perelson’s findings suggest that a vaccine should instead present the host with high levels of multiple diverse strains.

Luo and Perelson’s research was supported by the National Institute of Health through a grant to the Duke Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVI-ID). More on information on CHAVI-ID can be found here.

About Los Alamos National Laboratory

Los Alamos National Laboratory, a multidisciplinary research institution engaged in strategic science on behalf of national security, is operated by Los Alamos National Security, LLC, a team composed of Bechtel National, the University of California, BWX Technologies, Inc. and URS for the Department of Energy’s National Nuclear Security Administration.

Los Alamos enhances national security by ensuring the safety and reliability of the U.S. nuclear stockpile, developing technologies to reduce threats from weapons of mass destruction, and solving problems related to energy, environment, infrastructure, health, and global security concerns.

Related Articles Read More >

Five simple ways to improve project management processes for your R&D team
ENPICOM launches display solution to accelerate antibody selection while maximizing precision
Groundbreaking research could help paramedics save the lives of pedestrian casualties 
R&D 100 winner of the day: Slycat
2021 R&D Global Funding Forecast

Need R&D World news in a minute?

We Deliver!
R&D World Enewsletters get you caught up on all the mission critical news you need in research and development. Sign up today.
Enews Signup

R&D World Digital Issues

February 2020 issue

Browse the most current issue of R&D World and back issues in an easy to use high quality format. Clip, share and download with the leading R& magazine today.

Research & Development World
  • Subscribe to R&D World Magazine
  • Enews Sign Up
  • Contact Us
  • About Us
  • Drug Discovery & Development
  • Pharmaceutical Processing
  • 2022 Global Funding Forecast

Copyright © 2022 WTWH Media LLC. All Rights Reserved. The material on this site may not be reproduced, distributed, transmitted, cached or otherwise used, except with the prior written permission of WTWH Media
Privacy Policy | Advertising | About Us

Search R&D World

  • Home Page
  • Topics
    • Aerospace
    • Archeology
    • Automotive
    • Biotech
    • Chemistry
    • COVID-19
    • Environment
    • Energy
    • Life Science
    • Material Science
    • R&D Market Pulse
    • R&D Management
    • Physics
  • Technology
    • 3D Printing
    • A.I./Robotics
    • Battery Technology
    • Controlled Environments
      • Cleanrooms
      • Graphene
      • Lasers
      • Regulations/Standards
      • Sensors
    • Imaging
    • Nanotechnology
    • Scientific Computing
      • Big Data
      • HPC/Supercomputing
      • Informatics
      • Security
      • Software
    • Semiconductors
  • 2021 R&D 100 Award Winners
    • R&D 100 Awards
    • 2020 Winners
    • Winner Archive
  • Resources
    • Digital Issues
    • Podcasts
    • Subscribe
  • Global Funding Forecast
  • Webinars