
Cancer is a multistep process that involves a complex interplay between genetic and epigenetic alterations. Epigenetic modifications mediate changes in gene expression without altering the DNA sequence. One of those modifications, DNA methylation, was found to be significantly different between mouse models of medulloblastoma and primary medulloblastoma human samples.
The findings, published in the December 2013 Issue of Epigenetics, provide an opportunity to both better understand the mechanisms of aberrant DNA methylation in human cancer and construct better mouse models of human cancer for therapy development.
Date: December 5, 2013
Source: Landes Bioscience