Trevigen offers DNA repair gene knockdown cell lines, encompassing the Base Excision Repair (BER) pathway as well as Mismatch Repair (MMR), and Non-Homologous End Joining (NHEJ) for a total of 30 lines plus a control cell.
DNA repair proteins maintain the stability of the genome. When repair protein function is impaired through mutations the genome may become unstable, which is a hallmark of solid tumors. The availability of these knockdown cell lines will permit scientists to study the molecular etiology of tumor genomic instability and to exploit it in oncology research.