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Findings suggest how swimming cells form biofilms on surfaces

By R&D Editors | September 11, 2014

This graphic illustrates how swimming microorganisms cause the stretching of polymers (elongated red, yellow and blue features) in a mucus-like substance, attracting the motile cells to surfaces in biofilms that foul everything from implantable medical devices to boat propellers. Image: Purdue Univ./Gaojin Li and Arezoo ArdekaniBacteria secrete a mucus-like “extracellular polymeric substance” that forms biofilms, allowing bacterial colonies to thrive on surfaces.

“They can form everywhere, on catheters used to transfer body fluids, prosthetic valves and other devices,” said Arezoo Ardekani (pronounced AH-Re-Zo Ar-de-KA-nee), an assistant professor in Purdue University’s School of Mechanical Engineering.

Costs associated with biofilms affecting implantable medical devices and various types of industrial equipment amount to billions of dollars annually. The slimy films grow on key surfaces in a range of applications, from boat propellers to the insides of industrial pipes, increasing wear and tear and fuel consumption and decreasing efficiency.

Attacking the biofilms using antibiotics and toxic chemicals has drawbacks including the evolution of antibiotic-resistant strains, which might be alleviated by finding ways to hinder bacterial adhesion without killing the bacteria.

Future approaches to controlling biofilms could hinge on discovering the precise motions of individual bacterial cells, which propel themselves using whip-like appendages called flagella.

Now, new findings reveal specifics about interactions that induce bacteria to swim close to surfaces, where they remain long enough to attach and form biofilms.

The findings appeared in a special early career issue of the journal Rheologica Acta, published on Aug. 31. The paper was authored by Purdue doctoral student Gaojin Li, former University of Notre Dame postdoctoral research associate Alireza Karimi, and Ardekani.

The extracellular polymeric substance is sticky—or viscoelastic—and contains polymers such as polysaccharides, proteins and DNA.

The researchers are learning how the swimming mechanics of microorganisms are affected by these polymers as they draw near surfaces.

“Most research done on hydrodynamic interaction of bacteria on surfaces neglects the role of these polymers,” Ardekani said. “And what we show is that this extracellular polymeric substance can also change the hydrodynamic forces that lead to bringing these cells close to the surface.”

The researchers studied the motion of motile organisms using a swimming model called a squirmer. The model allows researchers using computers to simulate three modes of propulsion employed by the microorganisms: pulling or pushing themselves using flagella either in the front or back, respectively, and neutral, in which tiny cilia are located around a spherical organism.

Most bacteria are pushers, and the findings showed that pushers swim closer to surfaces in the presence of the extracellular polymeric substance.

“They get closer and they stay closer as we increase the concentration of polymers,” Ardekani said

Effects of solid boundaries on swimming dynamics of microorganisms in a viscoelastic fluid

Source: Purdue Univ.

 

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