amsbio has introduced TRU Block, a highly potent reagent that actively blocks the heterophilic antibody (HA) interference in immunoassays including but not limited to Human Anti-Mouse Antibody (HAMA) interference.
Heterophilic antibodies are a group of human antibodies against animal IgG. HA interference is a well known interference factor in diagnostic assays, often causing false positive or false negative results. The frequency of such interference is low, but false results have significant impact on the quality and competitiveness of the diagnostic assays as well as on the lives of those individuals who have been falsely diagnosed.
TRU Block offers many advantages over traditional Mouse IgG reagents, which inhibit HAMA by serving as antigens of HAMA. TRU Block uses a proprietary active mechanism and is 5-20 times more effective than Mouse IgG on HAMA blocking thereby reducing blocker usage. TRU Block works well on HAMA as well as other types of HA while Mouse IgG is effective only on HAMA, according to the company.
Extensive quality control (including a HAMA blocking functional assay, purity and bioburden testing) ensures that every batch of TRU Block is well characterized. Guaranteed as greater than 95% pure – the high purity of TRU Block delivers highly consistent performance. Excellent lot-to-lot consistency further reduces the need for adjusting assay reagents to optimize performance.