Research & Development World

  • Home Page
  • Topics
    • Aerospace
    • Archeology
    • Automotive
    • Biotech
    • Chemistry
    • COVID-19
    • Environment
    • Energy
    • Life Science
    • Material Science
    • R&D Market Pulse
    • R&D Management
    • Physics
  • Technology
    • 3D Printing
    • A.I./Robotics
    • Battery Technology
    • Controlled Environments
      • Cleanrooms
      • Graphene
      • Lasers
      • Regulations/Standards
      • Sensors
    • Imaging
    • Nanotechnology
    • Scientific Computing
      • Big Data
      • HPC/Supercomputing
      • Informatics
      • Security
      • Software
    • Semiconductors
  • 2021 R&D 100 Award Winners
    • R&D 100 Awards
    • 2020 Winners
    • Winner Archive
  • Resources
    • Digital Issues
    • Podcasts
    • Subscribe
  • Global Funding Forecast
  • Webinars

Horizon Discovery, Promega to develop next-gen predictive human disease models

By R&D Editors | November 9, 2011

Horizon Discovery
Ltd. announced a strategic partnership agreement with Promega Corporation. The
partnership centers on the delivery of endogenous gene reporting capabilities
in the form of Promega’s luciferase and HaloTag reporter technologies, using
Horizon’s proprietary homologous recombination-based precision genome editing
technology (rAAV GENESIS).

The scientific
objective of the partnership is to develop next-generation predictive human
disease models, recapitulating genetic mutations exactly as they occur in
patient tumors, thereby enabling the elucidation of protein expression and
protein-protein interactions encoded by those mutations. To date, Horizon has
applied its rAAV gene-editing platform to reconstitute over 370 cancer
mutations and variations in human cell lines that serve as patient-relevant,
predictive in vitro models of genetic
disease.

Additional objective(s) will be to enable the study of
tumor response to anticancer treatments in real time, by offering in vivo xenografts of Horizon’s
tumorigenic engineered isogenic cell lines with incorporated Promega reporter
tags. Preliminary studies have revealed clear images of tumor graft
response to targeted molecular therapies. This
capability adds to drug discovery scientists’ existing toolbox of patient
relevant models to support the development of a greater number of more
efficacious anti-cancer drugs.

Horizon Discovery Ltd., www.horizondiscovery.com

Related Articles Read More >

2022 Global Funding Forecast: Strong R&D growth with clouds on the horizon
2022 Global Funding Forecast: R&D variants cover more than the pandemic
R&D firm BourkeHood helps startups claim over $100M
2022 R&D 100 Awards now open for submissions
2021 R&D Global Funding Forecast

Need R&D World news in a minute?

We Deliver!
R&D World Enewsletters get you caught up on all the mission critical news you need in research and development. Sign up today.
Enews Signup

R&D World Digital Issues

February 2020 issue

Browse the most current issue of R&D World and back issues in an easy to use high quality format. Clip, share and download with the leading R& magazine today.

Research & Development World
  • Subscribe to R&D World Magazine
  • Enews Sign Up
  • Contact Us
  • About Us
  • Drug Discovery & Development
  • Pharmaceutical Processing
  • 2022 Global Funding Forecast

Copyright © 2022 WTWH Media LLC. All Rights Reserved. The material on this site may not be reproduced, distributed, transmitted, cached or otherwise used, except with the prior written permission of WTWH Media
Privacy Policy | Advertising | About Us

Search R&D World

  • Home Page
  • Topics
    • Aerospace
    • Archeology
    • Automotive
    • Biotech
    • Chemistry
    • COVID-19
    • Environment
    • Energy
    • Life Science
    • Material Science
    • R&D Market Pulse
    • R&D Management
    • Physics
  • Technology
    • 3D Printing
    • A.I./Robotics
    • Battery Technology
    • Controlled Environments
      • Cleanrooms
      • Graphene
      • Lasers
      • Regulations/Standards
      • Sensors
    • Imaging
    • Nanotechnology
    • Scientific Computing
      • Big Data
      • HPC/Supercomputing
      • Informatics
      • Security
      • Software
    • Semiconductors
  • 2021 R&D 100 Award Winners
    • R&D 100 Awards
    • 2020 Winners
    • Winner Archive
  • Resources
    • Digital Issues
    • Podcasts
    • Subscribe
  • Global Funding Forecast
  • Webinars