Internal Glovebox Pressure By R&D Editors | August 3, 2012 Should the internal glovebox pressure be positive, negative, or adjustable? Hazardous particulates inside a glovebox should be kept under negative pressure. Maintaining a sterile environment inside a glovebox may require positive pressure. This cleanroom tip was taken from “What’s in a Name? Sometimes, Not So Much,” which appeared in the July/August 2012 issue of Controlled Environments.