Integrated DNA Technologies (IDT), the world leader in oligonucleotide synthesis, is enabling cancer research with its latest next-generation sequencing (NGS) product, the xGen Acute Myeloid Leukemia Cancer Panel v1.0. Consisting of 11,743 xGen Lockdown Probes, this cancer panel targets over 260 clinically relevant genes that were found to be mutated in a study of 200 patients with acute myeloid leukemia (AML), and published by The Cancer Genome Atlas consortium. The AML Cancer Panel is used for enriching the genome for regions of interest before performing NGS. It can, therefore, be used to study disease occurrence and progression, and help with the development of better targeted therapies.
Target enrichment enables users to focus their sequencing efforts on specific regions of the genome, providing a cost-effective and reliable alternative to whole genome sequencing, making NGS more accessible to researchers. By including only relevant xGen Lockdown Probes, the AML Cancer Panel enables high coverage of targeted regions, with minimal GC bias.
As cancer is a genetic disease driven by both heritable and somatic mutations, NGS technologies can significantly improve its detection, management, and treatment. DNA from a patient could be enriched for these AML-related genes using capture panels such as the xGen AML Cancer Panel and sequenced to identify mutated genes. Subsequently, the patient would receive therapy specific to their cancer profile. Periodic sequencing of these genes would allow monitoring of disease progression for both research and clinical purposes. As such, more tailored therapies can be developed and a personalised treatment regimen can be implemented.
Date: October 24, 2013
Source: Integrated DNA Technologies