Qlucore Omics Explorer 3.1 advanced data analysis software features a well-defined open interface to R. The interface allows users to utilize a broad range of statistical tests, to use existing tests in R, and to write new ones. The inbuilt statistical functions of the bioinformatics program are extended with the R interface to include the full suite of statistical methods available in R. Researchers do not need to be skilled with R to use and access the scripts. Instead, bioinformaticians are able to do script development and, once the R scripts are in place, to select from a dropdown box in the statistics dialog. The program ships with two R scripts supporting tests based on Limma and Wilcoxon methods. Other features include a flexible color scale, where the scale can be configured with a center color. All 2-D plots can be exported in the .tiff format.