Scientists from the University of Oxford’s Engineering Science Department and the Oxford Suzhou Center for Advanced Research (OSCAR) have developed a rapid testing technology for the novel coronavirus SARS-CoV-2 (COVID-19). The team, led by Prof. Zhanfeng Cui and Prof. Wei Huang, have been working to improve test capabilities as the virus spreads internationally.
The new test is much faster and does not need a complicated instrument. Previous viral RNA tests took 1.5 to 2 hours to give results. The research team has developed this new test, based on a technique which is capable of giving results in just half an hour – over three times faster than the current method.
Prof Wei Huang says: "The beauty of this new test lies in the design of the viral detection that can specifically recognize SARS-CoV-2 (COVID-19) RNA and RNA fragments. The test has built-in checks to prevent false positives or negatives and the results have been highly accurate."
Additionally, the technology is very sensitive. This means that patients in early stages of infection may be identified sooner, potentially helping to reduce the spread of the coronavirus SARS-CoV-2 (COVID-19). The technology only requires a simple heat-block which maintains a constant temperature for RNA reverse transcription and DNA amplification, and the results can be read by the naked eye. This makes it potentially useful in rural areas or community healthcare centers.
The technology has been validated with real clinical samples at Shenzhen Luohou People’s Hospital in China. The hospital has applied the rapid detection kits on 16 clinic samples, including 8 positives and 8 negatives, which have been confirmed by conventional RT-PCR methods and other clinical evidence. The test results using the rapid detection kits were all successful.
"I am proud of our team that has developed a useful technology and can make a contribution in combating CoV-19, and we are very grateful to the hospital’s medical team led by Dr Xizhou Sun, Dr Xiuming Zhang and Dr Dan Xiong for their part in testing this new technology," said Prof. Zhanfeng Cui, the Director of OSCAR.
The Oxford scientists are now working to develop an integrated device so that the test can be used at clinics, airports or even for home use.
The project was initiated by Oxford Suzhou Center for Advanced Research (OSCAR), a University of Oxford center in Suzhou Industrial Park. The experiments to develop the technology were performed in the Department of Engineering Science at the University of Oxford.
For more information please contact Prof. Zhanfeng Cui
Credit: University of Oxford