Needle-free nanotechnology developed at The University of Queensland has been used to successfully deliver an inactivated poliovirus vaccine.
Delivery of a polio vaccine with the Nanopatch was demonstrated by UQ’s Professor Mark Kendall and his research team at UQ’s Australian Institute for Bioengineering and Nanotechnology, in collaboration with the World Health Organization, the Centers for Disease Control and Prevention, and vaccine technology company Vaxxas.
Kendall says the Nanopatch had been used to administer an inactivated Type 2 poliovirus vaccine in a rat model.
“We compared the Nanopatch to the traditional needle and syringe, and found that there is about a 40-fold improvement in delivered dose-sparing,” Kendall says.
“This means about 40 times less polio vaccine was needed in Nanopatch delivery to generate a functional immune response as the needle and syringe.
“To our knowledge, this is the highest level of dose-sparing observed for an inactivated polio vaccine in rats achieved by any type of delivery technology, so this is a key breakthrough.”
The next step will be clinical testing.
Dr. David Muller, first author of the research published in Scientific Reports, says the work demonstrated a key advantage of the Nanopatch.
“The Nanopatch targets the abundant immune cell populations in the skin’s outer layers; rather than muscle, resulting in a more efficient vaccine delivery system,” he says.
Clinical success and widespread use of the Nanopatch against polio could help in the current campaign to eradicate polio. It could be produced and distributed at a cheaper cost, and its ease of use would make it suitable for house-to-house vaccination efforts in endemic areas with only minimal training required.
World Health Organization Global Polio Eradication Initiative Director Michel Zaffran says only Afghanistan and Pakistan remain polio-endemic, but all countries are at risk until the disease is eradicated everywhere.
“Needle-free microneedle patches such as the Nanopatch offer great promise for reaching more children with polio vaccine as well as other antigens such as measles vaccine, particularly in hard-to-reach areas or areas with inadequate healthcare infrastructure,” Zaffran says.
Nanopatch technology is being commercialized by Vaxxas Pty Ltd, which has scaled the Nanopatch from use in small models to prototypes for human use.
Vaxxas CEO David Hoey says the first human vaccination studies are scheduled for this year.
“Key attributes of the Nanopatch, including its ease of use and potential to not require refrigeration, could improve the reach and efficiency of vaccination campaigns in difficult-to-reach locations, including those where polio remains endemic,” Hoey says.
The work was funded by the World Health Organization, Vaxxas, Rotary District 9630, and the Rotary Foundation.
Source: The University of Queensland