Thermo Fisher Scientific Inc. has released the Maybridge HitFinder-Plus, a collection of 3,000 pre-plated drug-like screening compounds designed for drug discovery programs. The library expands the Maybridge HitFinder collection of 14,400 screening compounds and is available as an “add-on” for current HitFinder users at reduced upgrade fees.
Thermo Fisher created the HitFinder-Plus collection using a clustering algorithm, based on standard Daylight Fingerprints and a Tanimoto level of 0.55, to select a statistically representative sample of the full 56,000 compound Maybridge Screening Collection. All compounds fit Lipinski Ro5 guidelines for “drug-likeness” and have a purity level of greater than 90%. They have also been selected to be non-reactive, ensuring fewer false positives and higher-quality results.
When combined, the pre-plated Maybridge HitFinder and HitFinder-Plus collections contain more than 17,400 unique drug-like screening compounds, providing a large, but manageable library that is flexible enough for a range of drug discovery programs. These pre-selected, diverse collections are conveniently supplied as dry films in Thermo Scientific Matrix 96-shallow-well plates or 384-well microplates. For further convenience, users can view and assess the exact structures in each plate by browsing the collections online at www.chem.maybridge.com/hitfinder. This ensures that the process of identifying potential drug leads using Maybridge compounds is as easy and cost-effective as possible.