GeneTex, a leading manufacturer of antibodies and antibody-related reagents, has announced that they will be launching a new line of antibodies against Hice1 and Hec1. Both of these targets are key players in spindle assembly.
Hice1 is a novel microtubule-associated protein that is required for the maintenance of spindle integrity and chromosomal stability, and the phosphorylation of Hec1 by Nek2 kinase has been shown to modulate chromosome alignment and signaling of the spindle assembly checkpoint. The interaction between Hec1 and Hice also contributes to mitotic centrosomal microtubule growth for proper spindle assembly.
GeneTex’s new product line will include a phospo Ser 55 Hec1 antibody, a non-phospho Ser 55 Hec1 antibody, a phospo Ser 76/77 Hec1 antibody, a non-phospho Ser 76/77 Hec1 antibody, a phospo Ser 165 Hec1 antibody, a non-phospho Ser 165 Hec1 antibody, a phospho Ser 19/20 Hice1 antibody, a non-phospho Ser 19/20 Hice1 antibody, as well as corresponding blocking peptides. A complete listing of Hec1 and Hice1 antibodies is available at http://www.genetex.com/Hec1_Hice1.
The study of spindle assembly has widespread applications, as this process is critical for efficient mitotic progression and accurate chromosome segregation. Errors in this process often lead to structural and functional aberrations that result in the promotion of segregation errors and aneuploidy, a hallmark of most cancers.
GeneTex will be launching one of the largest collections of Hec1 and Hice1 antibodies that have been validated for western blotting, immunofluorescence (ICC/IF), immunohistochemistry (IHC) and other applications. Almost all of the antibodies in the line are antigen-affinity purified, which results in higher quality antibodies for research. GeneTex will also be offering smaller-sized vials of their zebrafish antibodies, allowing researchers the flexibility to try new antibodies at a much lower cost.