A promising compound for cancer treatment has been synthesized in a laboratory by an RMIT University researcher during his Ph.D. research.

 

Dr. Dan Balan, from the School of Applied Sciences at RMIT, said 15-aza-Salicylihalamide A analogue had demonstrated potent activity against several leukemia cell lines.

 

“Salicylihalamide A is an interesting natural marine product that has been isolated from a marine sponge of the genus Haliclona, collected from waters around Rottnest Island, 18 km off the coast of southern Western Australia,” Balan said.

 

Salicylihalamide A is cytotoxic- or a toxin which is known to destroy cells and which also provides a defense for the sea sponge.

 

“My goal was to synthesize the chemical in the laboratory in the form of a single aza-salicylihalamide A analogue molecule,” he said.

 

The aza-salicylihalamide A analogue molecules were then exposed to NCI-60 leukemia cell lines, and exhibited anti-proliferating effects on the group of cells at highly diluted or “sub-molar” concentrations.

 

“15-aza-Salicylihalamide A Analogue has proven to be very active against various types of cancer, but it was clearly most active against HL-60, which is acute promyelocytic leukemia,” he said.

 

Other findings revealed it to be an inhibitor of vacuolar ATPase and proton pumps, frequently found in metastatic cancer cells- which are cancer cells that have migrated through the bloodstream from more advanced tumors.

 

“The molecule was synthesized in a short molecular sequence that could be easily produced in very large volumes for drug production,” Balan said.

 

He explained there will be further research to investigate its effectiveness on different cancers, potentially leading to extensive drug development.

 

Balan’s Ph.D. research was funded by RMIT University and he was co-supervised by Associate Professor Helmut Hugel, RMIT University and Professor Mark Rizzacasa, Bio 21, University of Melbourne.

 

Date: February 6, 2014

Source: RMIT University