Traditional CRISPR-Cas9 methods have revolutionized genetics, but large functional sections of DNA, called payloads, still cannot be inserted into the genome without compromising cell viability or creating unwanted effects. Standard Homology-Directed Repair (HDR) dramatically loses efficacy for payloads exceeding 1 kilobase, compromising cell viability and increasing off-target edits. The 1 kb problem CRISPR, which stands…
Three scientists win Nobel Prize for immune system research
Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi were awarded the Nobel Prize in Physiology or Medicine on Monday for immune system research that has contributed to medical advances in cancer and autoimmune treatments. The researchers identified a class of cells called regulatory T cells and the genes that control them. Their work revealed how…
This week in research: A space launch, breathing eyes, glaciers melting, and more
Could a new telescope unearth cosmic recipes for life? Can a cell patch rescue fading eyesight? And what’s with bubbles “galloping” in a lab? This week’s research roundup probes the surprising frontiers of astronomy, medicine, archaeology, and more — raising as many questions as it answers. Read on for highlights that challenge familiar assumptions and…