Research & Development World

  • R&D World Home
  • Topics
    • Aerospace
    • Automotive
    • Biotech
    • Careers
    • Chemistry
    • Environment
    • Energy
    • Life Science
    • Material Science
    • R&D Management
    • Physics
  • Technology
    • 3D Printing
    • A.I./Robotics
    • Software
    • Battery Technology
    • Controlled Environments
      • Cleanrooms
      • Graphene
      • Lasers
      • Regulations/Standards
      • Sensors
    • Imaging
    • Nanotechnology
    • Scientific Computing
      • Big Data
      • HPC/Supercomputing
      • Informatics
      • Security
    • Semiconductors
  • R&D Market Pulse
  • R&D 100
    • Call for Nominations: The 2025 R&D 100 Awards
    • R&D 100 Awards Event
    • R&D 100 Submissions
    • Winner Archive
    • Explore the 2024 R&D 100 award winners and finalists
  • Resources
    • Research Reports
    • Digital Issues
    • Educational Assets
    • R&D Index
    • Subscribe
    • Video
    • Webinars
  • Global Funding Forecast
  • Top Labs
  • Advertise
  • SUBSCRIBE

Thermo Fisher Scientific launches new, larger HyPerforma DynaDrive S.U.B.s for cell culture production

By Heather Hall | March 12, 2021

The Thermo Scientific HyPerforma DynaDrive S.U.B. (Single-Use Bioreactor) is now available in 3,000 L and 5,000 L models. The first-of-its-size 5,000 L S.U.B. is Thermo Fisher Scientific’s largest commercially available S.U.B., enabling biopharmaceutical companies to integrate single-use technologies into large-scale bioprocesses, including perfusion cell culture and cGMP manufacturing at very high cell density.

The DynaDrive portfolio – including the 50 L, 500 L and now expanded to 3,000 L and 5,000 L S.U.B.s – offers features that support cell culture performance across scales and accommodate high-density and next-generation cell culture processes. DynaDrive S.U.B.s also provide suitable turn-down in stirred tank reactors, reducing the number of vessels required for seed-train scale-up. By minimizing seed-train and enabling large-scale, high-intensity processes, the DynaDrive S.U.B.s reduce overall costs through reduced capital investment, reduced operational expenses, and higher-output processes.

Thermo Fisher launched its S.U.B. portfolio in 2006 and was the first supplier to launch a 2,000 L S.U.B. in 2011. The DynaDrive 50 L and 500 L models were launched in 2020 and introduced new features, including a unique impeller design, patented crossflow sparger technology and improved sensor technology. Thermo Fisher’s DynaDrive S.U.B.s are designed to deliver superior performance in single-use format and increased scalability for cell culture processes.

Key Applications include upstream bioprocessing for biologics production, process development (PD), GLP and cGMP cell culture production.

Features/Benefits:

  • Scalability: Cell culture performance from 50 L to 5,000 L in the HyPerforma DynaDrive S.U.B.s.
  • Superior turn-down ratio: Working volumes as low as 250 L in the 3,000 L and 5,000 L S.U.B.s, reducing the number of reactors required for seed train by as much as 50 percent, and improving sustainability and mix-through-drain.
  • Improved mixing: DynaDrive agitation drive-train with multiple impellers distributes power input and cubical design provides baffles in corners and better bioprocess container (BPC) fit.
  • Improved mass transfer: Proprietary laser-drilled hole spargers (DHS) for right-size bubbles to maximize oxygen delivery while balancing carbon dioxide stripping.
  • Optimized for modern cell culture processes: Mixing times, power input per volume (PIV), and mass transfer performance capable of supporting viable cell densities of >100 million cells/ml.
  • Proven quality: Robustly tested drivetrain integrated in the DynaDrive BPCs, which are made with superior Thermo Scientific Aegis 5-14 bioprocessing film.
  • Reduced vessel footprint: Minimized hardware optimized for perfusion cell culture processes to help save critical manufacturing suite space. The 3,000 L and 5,000 L share the same footprint.
  • Streamlined dataflow: Built with automation package and TruBio software powered by the DeltaV control platform from Emerson.

For more information, visit thermofisher.com/dynadrive

 

Related Articles Read More >

New ICP-OES series designed for complex matrices
Brandtech case studies tout 76% energy savings, $400K annual cost reduction from modular lab vacuum systems
How materials scientists are using (S)TEM to better understand our world on the atomic scale 
Chromium X (GEM-X Flex) instrument on the bench
10x CTO on Chan Zuckerberg, Arc Institute ties and industrializing single-cell biology
rd newsletter
EXPAND YOUR KNOWLEDGE AND STAY CONNECTED
Get the latest info on technologies, trends, and strategies in Research & Development.
RD 25 Power Index

R&D World Digital Issues

Fall 2024 issue

Browse the most current issue of R&D World and back issues in an easy to use high quality format. Clip, share and download with the leading R&D magazine today.

Research & Development World
  • Subscribe to R&D World Magazine
  • Enews Sign Up
  • Contact Us
  • About Us
  • Drug Discovery & Development
  • Pharmaceutical Processing
  • Global Funding Forecast

Copyright © 2025 WTWH Media LLC. All Rights Reserved. The material on this site may not be reproduced, distributed, transmitted, cached or otherwise used, except with the prior written permission of WTWH Media
Privacy Policy | Advertising | About Us

Search R&D World

  • R&D World Home
  • Topics
    • Aerospace
    • Automotive
    • Biotech
    • Careers
    • Chemistry
    • Environment
    • Energy
    • Life Science
    • Material Science
    • R&D Management
    • Physics
  • Technology
    • 3D Printing
    • A.I./Robotics
    • Software
    • Battery Technology
    • Controlled Environments
      • Cleanrooms
      • Graphene
      • Lasers
      • Regulations/Standards
      • Sensors
    • Imaging
    • Nanotechnology
    • Scientific Computing
      • Big Data
      • HPC/Supercomputing
      • Informatics
      • Security
    • Semiconductors
  • R&D Market Pulse
  • R&D 100
    • Call for Nominations: The 2025 R&D 100 Awards
    • R&D 100 Awards Event
    • R&D 100 Submissions
    • Winner Archive
    • Explore the 2024 R&D 100 award winners and finalists
  • Resources
    • Research Reports
    • Digital Issues
    • Educational Assets
    • R&D Index
    • Subscribe
    • Video
    • Webinars
  • Global Funding Forecast
  • Top Labs
  • Advertise
  • SUBSCRIBE