DDD

Next-generation sequencing (NGS) tools have been a game-changer in the halls of drug discovery, where rapid and affordable sequencing has enabled faster characterization of samples, the ability to interrogate individual cells, and more frequent monitoring of cell lines for genetic drift, among other capabilities. While these platforms have contributed to significant advances in drug discovery…

Two towering JEOL Electron Microscopes stand ready to produce terabytes of valuable data for researchers at Generate:Biomedicines each day, who are accelerating drug discovery and development of novel therapeutics using machine learning and generative artificial intelligence. The two Transmission Electron Microscopes, the JEOL CRYO ARM 200 and CRYO ARM 300 are used in structural biology,…

Speedata, whose first-of-its-kind Analytics Processing Unit (APU) is designed to accelerate big data analytic workloads across industries, has announced the results of a simulation of its APU on a compound similarity analysis workload in the pharmaceutical industry. Using the APU, the analysis was completed in 19 minutes, compared to 90 hours when using a CPU…

By Mark Jones It looks innocuous in my hand, yet there are growing calls to ban it. It may use technology created for the Manhattan Project, but, in my hand, it doesn’t feel like a weapon. It feels natural, in spite of the very unnatural materials it may contain. I’m not at all cautious as…

RotaChrom has announced its rCPC platform conforms to Current Good Manufacturing Practices (cGMP) for the pharmaceutical industry, allowing the use of its rCPC purification and separation systems within cGMP-compliant laboratory and manufacturing environments. ”The GMP rCPC is a preparative purification platform that we specifically designed for the highly regulated pharmaceutical GMP environment,” said Andras Gaspar,…

Proscia, a provider of digital and computational pathology solutions, has announced that Virscio, a provider of translational research and development services, has deployed Concentriq for Research. The contract research organization (CRO) is leveraging Proscia’s flagship software platform to provide faster, more informed drug safety insights, helping its sponsors to improve research and development (R&D) efficiency.…

By Jesse Harris, Digital Marketing Coordinator, ACDLabs In September 2019 the FDA learned that the common heartburn products Zantac and Axid contained elevated levels of the carcinogen N-nitrosodimethylamine (NDMA). Ranitidine and nizatidine, the active ingredients in these medications, appeared to be the source of this impurity. By April 1, 2020, the FDA asked that all…

Thermo Fisher Scientific is adding early development work for oral solid dose therapies to its Bourgoin, France site, enabling that location to address customers’ workflow from early drug development through commercial manufacturing and underscoring the company’s commitment to helping clients get medicines to patients sooner. “In the last decade, Thermo Fisher has led and advanced…

Proscia, a provider of digital and computational pathology solutions, has strengthened its position in the $12 billion[1] preclinical R&D market. At the center of its expansion, the company is enhancing its flagship Concentriq for Research, trusted by 14 of the top 20 pharmaceutical companies as a singular software platform for pathology workflows and data, to…

From Purdue University Surgery, especially surgery to remove cancerous tumors, relies on a range of tools and techniques as well as on the skill of the surgeon. Now, new imaging agent Cytalux will make surgery to remove lung cancer tumors a little more exact. The inside of the human body famously looks nothing like an…

By Christian Olsen, Business Segment Lead, Dotmatics Biologic drugs have increasingly delivered treatments for cancer and rare diseases and continue to prove effective in other wide-ranging areas, from neurological and metabolic disorders to respiratory and cardiovascular diseases. But along with the incredible potential biologics offer, there is also great pressure to discover and deliver novel…

By Haydn Boehm, Director of Product Marketing, Dotmatics Despite the buzz around artificial intelligence (AI), most industry insiders know that the use of machine learning (ML) in drug discovery is nothing new. For more than a decade, researchers have used computational techniques for many purposes, such as finding hits, modeling drug-protein interactions, and predicting reaction…

Thermo Fisher Scientific Inc. has opened its largest single-use technology manufacturing site in Greater Nashville. The $105 million, 400,000-ft2 facility enables the company to help meet rapidly growing demand for the bioprocessing materials needed to produce vaccines and breakthrough therapies for cancer and other diseases. This new site is part of Thermo Fisher’s $650 million…

Dotmatics, a maker of R&D scientific software that connects science, data and decision-making, announces the release of its Small Molecule Drug Discovery Solution, an integrated scientific R&D platform with pre-configured workflows and expanded data management capabilities. The solution helps companies innovate more easily and expedites time to deployment by leveraging best practices derived from the…

Shimadzu Scientific Instruments announces the successful commercialization of a new Amyloid Mass Spectrometry (MS) Service for the early screening of amyloid-positive individuals. This simple, research-use-only blood-based analysis method enables reliable characterization of amyloid pathology in the brain with an easy-to-acquire blood sample to assist in the evaluation and development of new pharmaceutical treatments for Alzheimer’s…

The Pistoia Alliance is announcing that it has successfully completed a proof of concept (PoC) on the digital transfer via cloud of analytical High Performance Liquid Chromatography (HPLC) methods, proving it is possible to move analytical methods securely between two different vendors and Chromatography Data Systems (CDS) vendors with ease. This PoC delivers on a…

Two Rutgers engineers specializing in the process of making drugs derived from living organisms have created an analytical tool they expect will accelerate the discovery and production of biologic drugs that are often at the cutting edge of biomedical research. In an article that is the cover story in the American Chemical Society journal, Analytical…

By Rob Taylor, Pharmaceutical Segment Manager, Malvern Panalytical Sometimes you must take things apart to rebuild them. For a child with a LEGO masterpiece, this can be heartbreaking. But in the world of pharmaceuticals, reverse-engineering drugs is crucial for the development of less expensive, more accessible generic products. Chemical and structural reverse engineering, also known…

For 2022, U.S. industrial organizations are expected to collectively invest $447 billion in R&D efforts, or about 65.8% of the total R&D monies invested by the U.S. ($679.4 billion). That industrial investment is more than all other global countries except for China. The U.S. federal government is expected to invest $181.4 billion in R&D in…

Researchers live in a world of variants — coronaviral variants are taking center stage in the media right now. But in 2022, researchers will also have to deal with the challenges of accelerating economic inflation rates, global warming, electrification of everything, fifth- and sixth-generation broadband uncertainties, declining animal and plant diversities, declining global population rates,…

PerkinElmer. will be at The American Association for Cancer Research (AACR) Annual Meeting from April 8-13 in New Orleans (booths #1009, #1851 and #909), alongside its partner companies showcasing how genomic and cellular solutions for cancer research can be used to study its mechanisms, improve biomarker discovery, and help drive targeted, therapeutic discovery leading to…

Sepha, the Northern Ireland-based manufacturer of pharmaceutical packaging and equipment, has developed a new compact small-batch blister packaging machine with full traceability and electronic data storage capabilities. The EZ Blister+ meets increased demand for 21 CFR Part 11 compliant micro-batches throughout the blister production lifecycle, from R&D right through to commercial production. It will launch…

GenNext Technologies, a growth-stage company providing biopharmaceutical drug discovery systems and services, announced the receipt of a two year, Phase II SBIR grant for a project titled “In-Cell Automated Flash Oxidation (IC-AutoFox) Protein Footprinting System.” The grant was awarded by the National Institute of General Medical Systems (NIGMS) of the U.S. Department of Health and…

Genomenon Inc., an AI-driven genomics company, announces the completion of a $20 million Series B financing round. The funds will expand the company’s commercial operations and the development of its genomic data hub, which serves genetic testing labs, hospitals, pharmaceutical, and biopharma companies. Genomenon leverages AI (Artificial Intelligence) to organize the world’s genomic knowledge and…

Thermo Fisher Scientific and Symphogen, an affiliate of the pharmaceutical company Servier, announce the continuation of their collaboration to provide biopharmaceutical discovery and development laboratories with innovative tools and streamlined workflows for efficient characterization of complex therapeutic proteins. Since the collaboration began in 2018, Symphogen has adopted new and innovative instruments and software to improve…