Trophos SA, a clinical stage pharmaceutical company developing innovative therapeutics from discovery to clinical validation for indications with under-served needs in neurology and cardiology, announces that Trophos and partners in the European Union funded MitoTarget consortium presented four posters at the Society for Neuroscience (SfN) Meeting, 13th – 17th November, in San Diego, USA. The data presented demonstrate the potential for treating a range of neurodegenerative diseases including Alzheimer’s Disease and Huntington’s Disease by targeting mitochondrial dysfunction and also focused on mechanisms involved in neuronal metabolism and death.
“We are very pleased to present with our partners this important work, conducted in collaboration with a distinguished international scientific consortium,” said Rebecca Pruss, CSO at Trophos. “Mitochondrial dysfunction is increasingly recognized as a key target in developing effective treatments for neurodegenerative diseases. These first data coming from the various MitoTarget research program are very encouraging and will be complemented by a range of ongoing and planned studies during the remainder of the MitoTarget project. At the same time a key part of the MitoTarget project, the pivotal clinical study of Trophos’ mitochondrial pore modulator, olesoxime, in over 500 patients with Amyotrophic Lateral Sclerosis, is proceeding on track, with results expected in the fourth quarter of next year.”
MitoTarget is a three year collaborative project started in February 2009 for which the European Commission has awarded a three year grant of nearly EUR 6 million. MitoTarget is being carried out by an international consortium of 17 partners comprising of leading Western European treatment and research centres, led by Trophos. MitoTarget forms part of the Seventh Framework Programme of the European Community for Research, Technological Development and Demonstration Activities and has two main goals: to investigate the efficacy and safety of Trophos compound olesoxime (TRO19622) in a pivotal clinical study in Amyotrophic Lateral Sclerosis (ALS) patients and to develop the understanding of mitochondrial dysfunction and therapeutic potential of a novel proprietary class of molecules in neurological diseases.
Date: November 18, 2010
Source: Trophos