ATCC (American Type Culture Collection)’s collection of Tissue-Specific Tumor Cell Panels combine well-characterized adherent cell lines that were selected for genomic mutations as found in the Sanger COSMIC database. The cell lines are easy to grow using standard media formulations and possess critical genetic abnormalities found in tumors, the company reports.
Each panel is comprised of different cell lines that have been grouped by tissue of tumor origin. In developing the panels, scientists evaluated 20 different genes associated with tumorigenesis, including TP53, CDKN2A, BRAF, and KRAS. , Descriptive information for each cell line has been annotated with details regarding known mutations in select oncogenes and/or receptors.
There are 10 Tissue-Specific Tumor Cell Panels in the collection, including panels for breast cancer, triple-negative breast cancer, lung cancer, ovarian cancer, colon cancer, liver cancer, and pancreatic cancer.