Testing the effectiveness of new pharmaceuticals may get faster thanks to a
new technique incorporating quantum dots developed at the University of Central
Florida (UCF).
Some drug testing can take a decade or more, but UCF associate professor
Swadeshmukul Santra and his team have created an electronic quantum dots
(Qdots) probe that “lights up” when a drug it is delivering attaches to cancer
cells. The research appears online in Biomaterials.
A researcher can use a microscope to see where and how much of the drug has
been delivered because the probe emits a reddish color under special lighting
or via MRI because of its optical and magnetic components.
As the drug testing continues, images can be taken over and over without any
loss of optical or MRI signal. Researchers can then measure the size of the
tumor and number of cancer cells that “light up” compared with the original
untreated tumor.
This provides a way to determine whether the drug is doing what it is
supposed to be doing in the targeted areas. The technique is much easier than
the current process of removing treated cancer tumors and weighing them at
regular intervals to determine the drug’s efficiency in an animal.
“Many people in my area have been studying this approach for years,” Santra
says. “But we have now moved it into a live cell, not just in test tubes.”
Sudiptal Seal, the director of UCF’s NanoScience Technology
Center and nanoscience scientist
believes Santra’s research is significant.
“This is indeed a major breakthrough in Qdot research,” Seal says. “This new
diagnostic tool will certainly impact the field of nanomedicine.”
Santra and his team used semiconductor Qdots to create the probe. Because of
their small size and crystal-like structure, Qdots display unique optical and
electronic properties when they get excited. These unique properties make them
ideal for sustained and reliable imaging with special lights.
For this research, funded by the National Science Foundation and National
Institutes of Health, the UCF-led team used a superparamagnetic iron oxide
nanoparticle core decorated with satellite CdS:Mn/ZnS Qdots which carried the
cancer-fighting agent STAT3 inhibitor. The Qdot optical signal turned on when
the probe bonded with the cancer cells.
“The potential applications for drug testing specifically for cancer research
are immediate,” Santra says.
