Wolfram SystemModeler 4.1 is a modeling and simulation environment for cyber-physical systems used in industries such as aerospace, automotive, pharmaceuticals, systems biology and electrical engineering. Key features include integration of Mathematica‘s complete suite for reliability analysis; import from tools such as Simulink, Flowmaster and IBM Rational Rhapsody enabled based on the FMI standard; import of subsystems, e.g. control system models from other tools, and integration with Modelica models; exchanging models without exposing intellectual property; organizing systems in series, parallel and other structures; and construction of hierarchical models containing reliability block diagrams and fault trees.