Thermo Fisher Scientific’s Vanquish UHPLC system can be used as a standalone system or with mass spectrometers. The monolithic case contains an instrument that combines the ruggedness of an integrated system with the flexibility and serviceability of a modular system. It stands about 25 percent lower than comparable modular stacks for safety and convenience in the laboratory. Central to the UHPLC system is the family of Accucore Vanquish UHPLC columns, which feature 1.5-µm solid core particles utilizing Core Enhanced Technology to take advantage of the system’s 1,500 bar (22,000 psi) maximum pump pressure and flow rate up to 5 mL/min for ultra-short diffusion path lengths and highly efficient separations.