Bioinformatics 2003 Readers’ Choice Finalist: Sybyl/Base
SYBYL/Base is the heart of Tripos’ Discovery Software, providing the fundamental components for understanding molecular structure and properties with a special focus on the creation of new chemical entities. It provides construction, editing, and visualization tools for both large and small molecules. Data organization and analysis rely on the Molecular Spreadsheet, which integrates chemical information with standard data manipulation tools. Its programming language and open architecture facilitate customized drug design methods.