Scientists engineer nanoscale vaults to encapsulate ‘nanodisks’ for drug delivery
(University of California – Los Angeles) The first steps toward the development of the vault nanoparticle into a versatile and effective DDS are reported in this paper. The ability to encapsulate therapeutic compounds into the vault is a critical and fundamental obstacle in their development for small-molecule drug delivery. Recombinant vaults are engineered to encapsulate the highly insoluble and toxic hydrophobic compound all-trans retinoic acid (ATRA) using a vault-binding lipoprotein complex that forms a lipid bilayer nanodisk.
