Researchers at St. Jude Children’s Research Hospital have discovered that a protein critical to a process called liquid-liquid phase separation within the cell undergoes internal changes in conformation that are key to its function. The protein, nucleophosmin, is a kind of “smart glue” in a structure called the nucleolus inside the cell’s nucleus. In the…
Researchers Discover Fundamental Pathology Behind ALS
A team led by scientists at St. Jude Children’s Research Hospital and Mayo Clinic has identified a basic biological mechanism that kills neurons in amyotrophic lateral sclerosis (ALS) and in a related genetic disorder, frontotemporal dementia (FTD), found in some ALS patients. ALS is popularly known as Lou Gehrig disease. The researchers were led by J. Paul Taylor,…
