Research & Development World

  • R&D World Home
  • Topics
    • Aerospace
    • Automotive
    • Biotech
    • Careers
    • Chemistry
    • Environment
    • Energy
    • Life Science
    • Material Science
    • R&D Management
    • Physics
  • Technology
    • 3D Printing
    • A.I./Robotics
    • Software
    • Battery Technology
    • Controlled Environments
      • Cleanrooms
      • Graphene
      • Lasers
      • Regulations/Standards
      • Sensors
    • Imaging
    • Nanotechnology
    • Scientific Computing
      • Big Data
      • HPC/Supercomputing
      • Informatics
      • Security
    • Semiconductors
  • R&D Market Pulse
  • R&D 100
    • Call for Nominations: The 2025 R&D 100 Awards
    • R&D 100 Awards Event
    • R&D 100 Submissions
    • Winner Archive
    • Explore the 2024 R&D 100 award winners and finalists
  • Resources
    • Research Reports
    • Digital Issues
    • Educational Assets
    • R&D Index
    • Subscribe
    • Video
    • Webinars
  • Global Funding Forecast
  • Top Labs
  • Advertise
  • SUBSCRIBE

AVEO Pharmaceuticals Presents HGF Model

By R&D Editors | April 19, 2009

AVEO Pharmaceuticals, Inc. presented a novel human hepatocyte growth factor (HGF) knock-in model and announced data demonstrating strong preclinical activity of SCH 900105 (AV-299), a highly potent antagonist of hepatocyte growth factor/scatter factor (HGF/SF), at the American Association for Cancer Research (AACR) 100th Annual Meeting in Denver, Colorado. Additionally, data assessing Fibroblast Growth Factor Receptor-2 (FGFR-2) response to an FGFR antagonist in a novel FGFR-2 driven model were also highlighted.

“Preclinical data presented at AACR underscore the unique capability of our proprietary Human Response Platform to guide drug development strategies for our lead antibody candidate SCH 900105 (AV-299), currently in Phase 1 clinical development, and reinforce the broad potential of our rapidly maturing proprietary antibody pipeline,” stated Tuan Ha-Ngoc, president and chief executive officer of AVEO Pharmaceuticals. “Through internal antibody discovery efforts and selective in-licensing of targeted small molecule therapeutics, AVEO is building a diversified product pipeline and rapidly advancing toward its vision of becoming a fully integrated oncology company.”

The HGF/c-Met pathway in human cancer is frequently activated by stromal derived HGF. In order to recreate the tumor-stromal-endothelial interactions of HGF/c-Met axis in preclinical efficacy models, AVEO created a human HGF “knock-in” host strain, replacing the murine HGF gene with human HGF gene. Multiple paracrine models were established in this host strain, allowing the testing of SCH 900105 (AV-299) in a setting more relevant to human disease.

Preclinical data presented at AACR demonstrated that SCH 900105 (AV-299) is efficacious in glioblastoma multiforme, non-small cell lung cancer (NSCLC), and pancreatic cancer models. In the U87 GBM model, SCH 900105 (AV-299) administration resulted in complete regressions even after withdrawal of treatment. In addition, several combination studies performed with SCH 900105 (AV-299) and other targeted therapeutics, chemotherapies and anti-angiogenic agents demonstrated additive efficacy in vivo.

AVEO identified FGFR-2 as an important tumor maintenance gene utilizing its proprietary in vivo genetic screen technology. To further validate the target, and to create a FGFR-2 driven tumor model, AVEO applied its directed complementation technology to develop a novel FGFR-2 driven breast tumor model. Drug efficacy studies using a non-selective FGFR inhibitor resulted in pharmacodynamic inhibition of the introduced human FGFR2 protein and led to significant tumor growth inhibition.

Recent data from human correlative and mutational studies has implicated FGFR2 as a potentially important target in human breast cancer.

Release date: April 19, 2009
Source: AVEO Pharmaceuticals

Related Articles Read More >

IBM’s second-generation, 156-qubit Quantum Heron processors offer reduced error rates, 16× better performance, and 25× faster speeds than 2022 systems. The Heron can run quantum circuits with up to 5,000 two-qubit gate operations using Qiskit—nearly double what IBM achieved in 2023.
Quantum computing edges closer to biotech reality in Moderna-IBM pact
New nanopore sensor paves the way for fast, accurate, low-cost DNA sequencing
E. coli makes Tylenol from plastic waste
2025 R&D layoffs tracker hits 132,075 as Amazon CEO signals AI will cut more jobs
rd newsletter
EXPAND YOUR KNOWLEDGE AND STAY CONNECTED
Get the latest info on technologies, trends, and strategies in Research & Development.
RD 25 Power Index

R&D World Digital Issues

Fall 2024 issue

Browse the most current issue of R&D World and back issues in an easy to use high quality format. Clip, share and download with the leading R&D magazine today.

Research & Development World
  • Subscribe to R&D World Magazine
  • Enews Sign Up
  • Contact Us
  • About Us
  • Drug Discovery & Development
  • Pharmaceutical Processing
  • Global Funding Forecast

Copyright © 2025 WTWH Media LLC. All Rights Reserved. The material on this site may not be reproduced, distributed, transmitted, cached or otherwise used, except with the prior written permission of WTWH Media
Privacy Policy | Advertising | About Us

Search R&D World

  • R&D World Home
  • Topics
    • Aerospace
    • Automotive
    • Biotech
    • Careers
    • Chemistry
    • Environment
    • Energy
    • Life Science
    • Material Science
    • R&D Management
    • Physics
  • Technology
    • 3D Printing
    • A.I./Robotics
    • Software
    • Battery Technology
    • Controlled Environments
      • Cleanrooms
      • Graphene
      • Lasers
      • Regulations/Standards
      • Sensors
    • Imaging
    • Nanotechnology
    • Scientific Computing
      • Big Data
      • HPC/Supercomputing
      • Informatics
      • Security
    • Semiconductors
  • R&D Market Pulse
  • R&D 100
    • Call for Nominations: The 2025 R&D 100 Awards
    • R&D 100 Awards Event
    • R&D 100 Submissions
    • Winner Archive
    • Explore the 2024 R&D 100 award winners and finalists
  • Resources
    • Research Reports
    • Digital Issues
    • Educational Assets
    • R&D Index
    • Subscribe
    • Video
    • Webinars
  • Global Funding Forecast
  • Top Labs
  • Advertise
  • SUBSCRIBE