Deciphera Pharmaceuticals, a clinical-stage biopharmaceutical company focused on addressing key mechanisms of tumor drug resistance, announced that it closed a $52 million Series C financing led by Viking Global Investors LP, Redmile Group, and Sphera Global Healthcare Fund and joined by Deciphera’s existing investors including New Leaf Venture Partners. The proceeds will enable Deciphera to advance its pipeline of novel oncology products into later-stage clinical development.
“We are very pleased to have secured this Series C funding from an outstanding group of life science investors who recognize the potential of our clinical-stage pipeline of unique switch control kinase inhibitors,” said Michael D. Taylor, Ph.D., President and CEO of Deciphera Pharmaceuticals. “The proceeds of this financing will be used to advance development of DCC-2618 and DCC-3014 into later-stage clinical trials with the goal of delivering new therapies that address key resistance mechanisms to improve cancer treatment outcomes.”
DCC-2618 is a pan-KIT and PDGFRα kinase switch control inhibitor in clinical development for the treatment of KIT and/or PDGFRα-driven cancers, including gastrointestinal stromal tumors, glioblastoma multiforme and systemic mastocytosis. DCC-2618 is currently in Phase 1 clinical development in patients with advanced malignancies, including gastrointestinal stromal tumors, aggressive systemic mastocytosis and malignant gliomas. Updated results from the ongoing Phase 1 clinical study will be presented at the 2017 American Society of Clinical Oncology (ASCO) Annual Meeting taking place June 2 – 6, 2017 in Chicago, IL.
DCC-3014 was purposefully designed using the company’s proprietary switch control inhibitor platform to be a highly-specific macrophage immunomodulatory agent. In preclinical models, DCC-3014 has demonstrated potent inhibition of the colony stimulating factor 1 receptor (CSF1R), an important target for the treatment of many cancer indications. Deciphera reported preclinical data demonstrating potent macrophage checkpoint inhibition with DCC-3014 in multiple cancer models both as a single agent and in combination with a PD-1 inhibitor at the American Association for Cancer Research (AACR) Annual Meeting in April 2016. DCC-3014 is currently in Phase 1 clinical development in patients with advanced malignancies.