Proteins have become more important as active drugs in pharmaceuticals, such as therapeutic antibodies, and in the course of development the conformational changes of proteins and peptides must be determined. Typically, size-exclusion chromatography or circular dichroism spectroscopy is used for the prediction of the protein secondary structure, but, as described in a recent white paper from Bruker Optics, Fourier transform infrared (FT-IR) spectroscopy is much faster, acquiring information within one minute.
