Dr. Gang Zheng and a team of biomedical researchers have discovered a “smart” organic, biodegradable nanoparticle that uses heat and light in a controlled manner to potentially target and ablate tumors with greater precision.
The proof-of-concept findings, published online and designated a “very important paper” in the leading chemistry journal Angewandte Chemie, provide a viable approach to boosting the clinical utility of photo-thermal therapy in treating cancer, says Zheng, Senior Scientist at the Princess Margaret and Professor of Medical Biophysics at the University of Toronto. Zheng also holds the Joey and Toby Tanenbaum/Brazilian Ball Chair in Prostate Cancer Research.
In the lab, using phantom models, the “smart” nanoparticle the team has dubbed PEARLs — photo-thermal enhancing auto-regulating liposomes — showed how it can solve the two bottlenecks currently preventing more effective use of photo-thermal therapy with patients. These are overheating of tissue that can cause collateral damage during treatment, and the inability to ablate larger tumor volumes because the light stops travelling when it is absorbed.
Zheng, a chemist, explains, “Our smart nanoparticle is super cool. It can absorb light, generate heat and ablate the tumor. It’s a thermal sensor and once it reaches the desired ablation temperature of 55 C, it becomes invisible allowing the light to move deeper into more areas of tumor and repeat the treatment process.
“The result is a promising new way to heat and ablate larger volumes of tumor with minimal damage to surrounding tissues in a controlled and precise way. The next step is to conduct pre-clinical studies to test the concept further.”
For the past 10 years at the Princess Margaret, Zheng’s research has focused on advancing nanoparticle technology by harnessing light, heat and sound to advance tumor imaging and targeted treatment.
The research was funded by the Terry Fox Research Institute, Prostate Cancer Canada, the Canadian Institutes of Health Research, Ontario Institute for Cancer Research, the Natural Sciences and Engineering Research Council of Canada, the Canada Foundation for Innovation, the Tanenbaum Chair in Prostate Cancer Research, and The Princess Margaret Cancer Foundation.
Source: Princess Margaret Cancer Centre