Certara, a leading provider of drug discovery and development software and scientific consulting services, announced that it has released an updated version of Phoenix, the industry leading PK/PD modeling software platform that is used by more than 4,000 researchers at 2,000 institutions, including the FDA.
All Phoenix tools are accessed within a single graphical user interface for ease of use and can be used individually or together. Certara continues to offer free upgrades to the Phoenix products for all currently licensed users. The newly available products include Phoenix WinNonlin 6.3, Phoenix NLME 1.2, Phoenix Connect 1.3, AutoPilot Toolkit 2.1 for Phoenix, and IVIVC Toolkit 2.1 for Phoenix WinNonlin.
This release includes the first commercial implementation of the Quasi-Random Parametric Expectation Maximization (QRPEM) algorithm for population PK/PD modeling.
Key developments in this release include:
The QRPEM algorithm in Phoenix NLME is designed to be faster and more accurate than existing mixed effects modeling methods due to a vastly improved sampling method. For certain test cases, the QRPEM algorithm has been found to be between 2X and 5X faster than other similar EM methods.
This release of Phoenix Connect has increased support for the development of integrated workflows that include algorithms from third party software, such as NONMEM, SAS, S+ or R. In the latest release a PsN (Pearl speaks NONMEM) plug-in has been added to Phoenix to facilitate re-runs and storage of PsN runs. In addition, Phoenix now allows any of the third-party compute jobs to be executed remotely on a high performance compute cluster through a Remote Processing Server. These advances now allow Phoenix to more fully support pharmacometrics workflows based on either Phoenix NLME or third party software, truly supporting a user defined, best-of-breed environment.
PHX Connect plug-ins (NONMEM, R, SAS, S-plus) now allow users to edit scripts in the native 3rd party Graphical User Interface). The scripts can then be pulled back into Phoenix and stored within the Phoenix Project file.
Phoenix now contains many infrastructure improvements, such as 64-bit support, improved data handling, an improved Object Browser, re-usability of graph templates, improved graphing and many efficiency enhancements.