The NCLUS clinical ultrasound platform consists of a portable armature and optical head. The armature enables versatile patient viewing for ultrasound acquisition. The optical head houses miniaturized laser components—an ultrasound source and laser Doppler vibrometer (LDV) with flexible optical fibers—that generate and measure ultrasound in any desired array layout. The LDV system has two simultaneous receiver channels, which provide 0.5–10 MHz ultrasound bandwidth that yields image resolution comparable to that of state-of-the-art medical ultrasound. We have patented the optical wavelength selection and operational parameters that provide a consistent noncontact ultrasound source. The LDV employs a second patented detector design that balances the speckle variability from skin and tissue, making a consistent ultrasound receiver. The optical head also houses a high-frame-rate camera that records rapidly scanned laser positions on the skin surface. Laser positioning is automated using programmable fast-steering mirrors and is registered to provide a fixed reference frame and 3D volumetric images similar to those of MRI and CT.