Trevigen developed the first commercially available assay to use full length Tankyrase 1 enzyme and unmodified NAD substrate. This highly sensitive screening kit accurately identifies Tankyrase 1 inhibitors in an in vitro system. When compared to previously available tests, this assay improves the clarity and the accuracy of the experimental data.
Recently, oncology researchers have a peaked interest in Tankyrase 1, due to its apparent functional involvement in telomere length maintenance, sister telomere association, and mitotic spindle organization changes that are associate with cancer and aging. This enzyme has shown to drive tumor cell proliferation by activating the Wnt pathway. Tankyrase 1 Activity Assay is a highly sensitive ELISA kit that allows for accurate measurement of the inhibition activity, resulting in a curve with a large dynamic range. Currently, Trevigen offers the all-inclusive kits in colometric and chemiluinescent detection formats.