Houston Methodist researchers developed a new lab-on-a-chip technology that could quickly screen possible drugs to repair damaged neuron and retinal connections, like what is seen in people with macular degeneration or who’ve had too much exposure to the glare of electronic screens. In the May 9 issue of Science Advances, researchers led by Houston Methodist Research…
Researchers Identify Compound to Prevent Breast Cancer Cells From Activating in Brain
Researchers Identify Compound That Prevents Breast Cancer Stem Cells From Activating in the Brain
Researchers at Houston Methodist used computer modeling to find an existing investigational drug compound for leukemia patients to treat triple negative breast cancer once it spreads to the brain. The Houston Methodist researchers culled through thousands of existing drugs to see if they could identify a compound that would prevent cancer cells from spreading, or…
3D Mini-Brains Accelerate Research for Repairing Brain Function
The Houston Methodist Research Institute is making mini brains from human stem cells that put researchers on a fast track to repair the nervous system after injury or disease of the brain and spinal cord. Houston Methodist neuroscientist Robert Krencik, Ph.D., and his team have developed a new system to reduce the time it takes…
Old Malaria Drug Improves Cancer Treatment
A new study shows that a 70-year-old malaria drug can block immune cells in the liver so nanoparticles can arrive at their intended tumor site, overcoming a significant hurdle of targeted drug delivery, according to a team of researchers led by Houston Methodist. Many cancer patients do not respond to chemotherapies because the drugs never…
New Way to Treat Cholesterol May Be On The Horizon
Tailor-Made Nanoparticles Dodge Immune Cells
A Houston Methodist-led research team showed that the systemic administration of nanoparticles triggers an inflammatory response because of blood components accumulating on their surface. This finding may help researchers create more effective ways to avoid activating the immune system and more precisely direct therapies in patients. In the journal ACS Nano, the team of nanomedicine…
