Research & Development World

  • R&D World Home
  • Topics
    • Aerospace
    • Automotive
    • Biotech
    • Careers
    • Chemistry
    • Environment
    • Energy
    • Life Science
    • Material Science
    • R&D Management
    • Physics
  • Technology
    • 3D Printing
    • A.I./Robotics
    • Software
    • Battery Technology
    • Controlled Environments
      • Cleanrooms
      • Graphene
      • Lasers
      • Regulations/Standards
      • Sensors
    • Imaging
    • Nanotechnology
    • Scientific Computing
      • Big Data
      • HPC/Supercomputing
      • Informatics
      • Security
    • Semiconductors
  • R&D Market Pulse
  • R&D 100
    • Call for Nominations: The 2025 R&D 100 Awards
    • R&D 100 Awards Event
    • R&D 100 Submissions
    • Winner Archive
    • Explore the 2024 R&D 100 award winners and finalists
  • Resources
    • Research Reports
    • Digital Issues
    • R&D Index
    • Subscribe
    • Video
    • Webinars
  • Global Funding Forecast
  • Top Labs
  • Advertise
  • SUBSCRIBE

Injured Bone Repaired with New Stem Cell Technique

By Joo Hyeon Heo, UNIST | January 26, 2017

Pictured from left: Professor Youngkyo Seo of Life Sciences and Dr. Jitendra N. Tiwari of Chemistry in their lab at UNIST.

A recent study affiliated with UNIST has developed a new method of repairing injured bone using stem cells from human bone marrow and a carbon material with photocatalytic properties. This could lead to powerful treatments for skeletal system injuries, such as fractures or periodontal disease.

This research has been jointly conducted by Professor Youngkyo Seo of Life Sciences and Dr. Jitendra N. Tiwari of Chemistry, in collaboration with Professor Kwang S. Kim of Natural Science, Professor Pann-Ghill Suh of Life Sciences, and seven other researchers from UNIST.

In the study, the research team reported that red-light absorbing carbon nitride (C₃N₄) sheets lead to remarkable proliferation and osteogenic differentiation by runt-related transcription factor 2 (Runx2) activation, a key transcription factor associated with osteoblast differentiation.

The results of the study have been published in the January issue of ACS Nano journal. The research team expects that this research breakthrough could lead to enhancement of bone regeneration.

The use of human bone marrow-derived mesenchymal stem cells (hBMSCs) has been tried successfully in fracture treatment due to their potential to regenerate bone in patients who have lost large areas of bone from either disease or trauma. Recently, many attempts have been made to enhance the function of stem cells using carbon nanotubes, graphene, and nano-oxides.

In the study, Kim and Suh examined the C₃N₄ sheets. They discovered that this material absorbs red light and then emits fluorescence, which can be used to speed up bone regeneration. Professor Kim’s team synthesized carbon nitrogen derivatives from melamine compounds. Then, they analyzed the light-absorbing characteristics of C₃N₄ sheets at a wavelength range of 455 to 635 nanometers (nm). As a result, the C₃N₄ sheets were found to emit fluorescence at the wavelength of 635 nm when exposed to red light in a liquid state. At this time, the released electrons induced calcium to accumulate in the cytoplasm.

Suh conducted a biomedical application of this material. First, stem cells and cancer cells were cultured in a medium containing 200 μg/ml of C₃N₄ sheets. After two days of testing, the material showed no cytotoxicity, making it useful as biomaterials.

It was also confirmed that C₃N₄ sheets act on stem cells to differentiate into osteoblasts to promote mineral formation. In this process, the osteogenic differentiation marker genes (ALP, BSP, and OCN) proliferated. Moreover, the Rux2 (Runt-related transcription factor 2), a key factor in osteoblast differentiation was also activated. This resulted in the increased osteoblast differentiation and accelerated bone formation.

“This research has opened up the possibility of developing a new medicine that effectively treats skeletal injuries, such as fractures and osteoporosis,” says Professor Young-Kyo Seo. “It will be a very useful tool for making artificial joints and teeth with the use of 3D printing.”

He adds, “This is an important milestone in the analysis of biomechanical functions needed for the development of biomaterials, including adjuvants for hard tissues such as damaged bones and teeth.”

The research team expects that their findings affirm the potential of C₃N₄ sheets in developing bone formation and directing hBMSCs toward bone regeneration.

This research was carried out with the support of the National Honor Scientist Program and the technology development project of the aging source, which is promoted by the Korean Ministry of Science, ICT, and Future Planning.

Source: UNIST

Related Articles Read More >

Open-source Boltz-2 can speed binding-affinity predictions 1,000-fold
Thermo Fisher’s new Orbitrap Excedion Pro targets complex biotherapeutics for drug development
FDA’s new ‘Elsa’ AI set to expedite clinical protocol reviews
Waters touts six-fold robustness with new Xevo TQ Absolute XR
rd newsletter
EXPAND YOUR KNOWLEDGE AND STAY CONNECTED
Get the latest info on technologies, trends, and strategies in Research & Development.
RD 25 Power Index

R&D World Digital Issues

Fall 2024 issue

Browse the most current issue of R&D World and back issues in an easy to use high quality format. Clip, share and download with the leading R&D magazine today.

Research & Development World
  • Subscribe to R&D World Magazine
  • Enews Sign Up
  • Contact Us
  • About Us
  • Drug Discovery & Development
  • Pharmaceutical Processing
  • Global Funding Forecast

Copyright © 2025 WTWH Media LLC. All Rights Reserved. The material on this site may not be reproduced, distributed, transmitted, cached or otherwise used, except with the prior written permission of WTWH Media
Privacy Policy | Advertising | About Us

Search R&D World

  • R&D World Home
  • Topics
    • Aerospace
    • Automotive
    • Biotech
    • Careers
    • Chemistry
    • Environment
    • Energy
    • Life Science
    • Material Science
    • R&D Management
    • Physics
  • Technology
    • 3D Printing
    • A.I./Robotics
    • Software
    • Battery Technology
    • Controlled Environments
      • Cleanrooms
      • Graphene
      • Lasers
      • Regulations/Standards
      • Sensors
    • Imaging
    • Nanotechnology
    • Scientific Computing
      • Big Data
      • HPC/Supercomputing
      • Informatics
      • Security
    • Semiconductors
  • R&D Market Pulse
  • R&D 100
    • Call for Nominations: The 2025 R&D 100 Awards
    • R&D 100 Awards Event
    • R&D 100 Submissions
    • Winner Archive
    • Explore the 2024 R&D 100 award winners and finalists
  • Resources
    • Research Reports
    • Digital Issues
    • R&D Index
    • Subscribe
    • Video
    • Webinars
  • Global Funding Forecast
  • Top Labs
  • Advertise
  • SUBSCRIBE