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2025 R&D layoffs tracker: hardware and chips lead the year’s biggest cuts while biopharma pares pipelines

By Brian Buntz | October 3, 2025

Last updated: October 3, 2025

Top 10 layoffs at companies YTD in 2025 with sizable R&D operations as of October 3.

Top 10 layoffs at companies YTD in 2025 with sizable R&D operations as of October 3.

The heaviest R&D job losses this year cluster in hardware and semiconductors, with sizeable single events at Dell, Microsoft and Intel’s Oregon sites, while biopharma cuts are smaller per event but frequent as firms triage pipelines. Federal labs have also reduced staff amid budget uncertainty, including the CDC, NIH and NREL. Challenger’s latest report describes a stagnating labor market even as employers retool for AI and tariff pressures (Challenger, Gray & Christmas).

What leaders are saying

As companies navigate this wave of restructuring, executives frame the cuts through multiple lenses. Some emphasize strategic repositioning around emerging technologies. Carl Eschenbach, CEO of Workday, told AP News that “the increasing demand for AI has the potential to drive a new era of growth for Workday.” Similarly, an Intel spokesperson told OPB the company is “making these decisions based on careful consideration of what’s needed to position our business for the future.” Microsoft echoed this rationale, describing “organizational changes necessary to best position the company for success in a dynamic marketplace.”

For biopharma companies, the cuts reflect difficult portfolio decisions. Serge Saxonov, CEO of 10x Genomics, acknowledged to GEN that “our R&D operation definitely ended up being impacted in a substantial way.” NGM Bio, in a company statement to FierceBiotech, emphasized its narrowed focus: “HG and cancer cachexia are both devastating conditions with profound unmet need, and we are committed to advancing potential solutions for patients.” John Houston, then-CEO of Arvinas, framed his company’s 33% workforce reduction to CT Insider as a necessary step: “Although difficult, the workforce reduction is a prudent decision that we believe will right-size the company for future success.”

The energy sector faced its own reckoning. Tom Johnstone, Interim Chair of Northvolt, said in the company’s bankruptcy announcement that “this is an incredibly difficult day for everyone at Northvolt,” as the Swedish battery maker shed 2,800 workers amid insolvency.

Industry analysts place these individual decisions in broader context. Andrew Challenger, Senior Vice President at Challenger, Gray & Christmas, told Reuters that “right now, we’re dealing with a stagnating labor market, cost increases and a transformative new technology.”

A deeper look at the pattern

Hardware and semiconductors dominate big-ticket events in 2025: Dell’s headcount decline, Microsoft’s ~3% reduction and Intel’s Oregon filings set the scale; Northvolt’s insolvency added a large energy-storage event. Biopharma cuts recur as companies refocus spend, including Arvinas, Gilead, 10x Genomics and NGM Bio. Federal science reductions at the CDC, NIH and NREL add to the overall R&D picture.

Challenger’s September reading shows fewer announced cuts than August but the weakest seasonal hiring plans since 2009 (Challenger). Meanwhile, Yale’s Budget Lab and Brookings find stability rather than disruption in AI’s labor-market effects, suggesting 2025 reductions are driven more by portfolio, capex and budget cycles than immediate automation (Yale Budget Lab; Brookings).

Entries below reflect executed, publicly confirmed headcount changes reported between Jan 1 and Oct 3, 2025. Links point to primary coverage or official filings. Locations reflect where the cut was recorded or filed; multinational cuts are marked Global.

Company Location Headcount Date % Industry Country Source
Takeda Pharmaceuticals (U.S. sites) United States (various) 137 2025-10-03 n/a Pharmaceutical United States FierceBiotech
Sutro Biopharma South San Francisco & San Carlos, CA 54 2025-10-01 n/a Biotechnology – Clinical United States SFGATE (cites CA WARN)
Dell Technologies Round Rock, TX 12,000 2025-03-25 ~10% Technology – Hardware United States Yahoo/Reuters
Microsoft Global 6,000 2025-05-13 ~3% Technology – Software Global AP News
Intel (regional) Hillsboro, OR 2,392 2025-07-11 n/a Semiconductors United States OPB
Northvolt Sweden 2,800 2025-03-31 ~62% Energy (Batteries) Sweden Reuters
Autodesk San Francisco Bay Area, CA 1,350 2025-02-27 9% Technology – Software United States Reuters
Workday Pleasanton, CA (Global) 1,750 2025-02-05 8.5% Technology – Software United States Washington Post • Reuters
Oracle Redwood City, CA 143 2025-08-13 n/a Technology – Software United States SFGATE
Oracle Pleasanton, CA 45 2025-08-13 n/a Technology – Software United States SFGATE
Oracle Santa Clara, CA 101 2025-08-13 n/a Technology – Software United States Spokesman‑Review
Oracle Seattle, WA 101 2025-09-02 n/a Technology – Software United States Spokesman‑Review
Cisco Systems San Jose, CA 221 2025-08-21 n/a Technology – Hardware United States CRN
Bristol Myers Squibb Lawrenceville, NJ 516 2025-05-05 n/a Pharmaceutical United States NJ WARN (PDF) • FiercePharma
Gilead Sciences Foster City, CA 149 2025-05-27 n/a Pharmaceutical United States FiercePharma
Gilead Sciences Foster City, CA 104 2025-03-14 n/a Pharmaceutical United States FiercePharma
Roche Molecular Systems Santa Clara, CA 108 2025-05-28 n/a Life Sciences United States The Register
10x Genomics Pleasanton, CA 100 2025-05-12 8% Biotechnology – Tools United States GEN
NGM Bio South San Francisco, CA 85 2025-06-30 75% Biotechnology – Clinical United States CA WARN (PDF) • FierceBiotech
Arvinas New Haven, CT 131 2025-05-01 33% Biotechnology – Clinical United States Endpoints News
Lexeo Therapeutics New York, NY 11 2025-05-12 15% Biotechnology – Clinical United States BioSpace
Mammoth Biosciences Brisbane, CA 24 2025-05-05 13% Biotechnology – Discovery United States FierceBiotech
Unity Biotechnology South San Francisco, CA 16 2025-05-05 100% Biotechnology – Clinical United States SFGATE
Centers for Disease Control and Prevention Atlanta, GA 1,300 2025-02-15 ~10% Public Health United States Reuters/AP
National Institutes of Health Bethesda, MD 1,165 2025-02-16 ~6% Biomedical Research United States Reuters
National Renewable Energy Laboratory Golden, CO 114 2025-05-05 ~3% Government Research Lab United States Reuters
Rallybio Farmington, CT 9 2025-05-08 40% Biotechnology – Clinical United States Company PR • BioSpace
Insitro South San Francisco, CA ~65 2025-05-08 22% Biotechnology – Discovery United States BioSpace • STAT
LeddarTech Québec City, QC 138 2025-05-22 ~95% Transportation (Sensors) Canada Company PR
Climeworks Zurich 106 2025-05-21 22% Energy (DAC) Switzerland Company statement
Leap Therapeutics Cambridge, MA ~26 2025-05-13 ~50% Biotechnology – Clinical United States SEC 10‑Q (May 13) • SEC 10‑K (headcount)
Arsenal Biosciences South San Francisco, CA (and remote) 100 2025-09-22 ~50% Biotechnology – Cell Therapy United States SFGATE

Other confirmed reductions

These are verified reductions where companies disclosed a percentage (or a multi‑year target) but not a single executed headcount figure. We keep them here until filings specify numbers.

Company Location Headcount Date % Industry Country Source
Mersana Therapeutics Cambridge, MA – 2025-05-06 55% Biotechnology – Clinical United States Company PR
Kyverna Therapeutics Emeryville, CA – 2025-05-14 16% Biotechnology – Clinical United States Company PR
Korro Bio Cambridge, MA – 2025-05-08 20% Biotechnology – Genetic Medicines United States Company PR
Vor Bio Cambridge, MA – 2025-05-08 95% Biotechnology – Cell & Gene United States Company PR • SEC 8‑K
Allogene Therapeutics South San Francisco, CA – 2025-05-14 28% Biotechnology – CAR‑T United States SEC 10‑Q
Atara Biotherapeutics Thousand Oaks, CA (retaining ~23) – 2025-05-12 30% Biotechnology – Cell Therapy United States SEC 8‑K
Teva Pharmaceuticals (multi‑year) Global 2,900 (target by 2027) 2025-05-08 ~8% Pharmaceutical Israel/Global FiercePharma
Builder.ai (registered as Engineer.ai) London, UK – 2025-05-20 ~100% Technology – AI/ML United Kingdom Financial Times • Rest of World
Luminar Technologies Orlando, FL – 2025-05-20 n/a Transportation (LiDAR) United States Barron’s
Blink Charging Baltimore, MD – 2025-05-19 20% Energy (EV charging) United States Company PR

Method notes

We include only verifiable, executed reductions in the first table. Announced or multi‑year targets (e.g., Teva’s plan) are tracked separately until filings or company documents specify headcounts. Where sources reported only a percentage, we list the percentage and hold the numeric slot until a filing appears. We remove unverified items.

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