Trifluoroacetic acid (TFA) is widely used in organic synthesis because of its versatile properties, including volatility, solubility in organic solvents, and particularly its strength as an acid. Many chemical transformations are performed using TFA as a solvent or as an acid catalyst, including rearrangements, functional group deprotection, oxidation, reduction, condensation, hydroarylation, trifluoromethylation and solvolysis reactions.…