Developing a Standard Operating Procedure (SOP) for your isolators is a difficult task and depends on the very specific requirements of a facility’s processes and regulation in its industry. Here are some questions you should ask yourself.
1. What contaminants am I concerned about?
2. Would they contaminate my processes (inside) or the environment (outside)?
3. Are these contaminants inert, chemically-, biologically-, or radio-active?
4. What contamination limits have to be considered?
5. The use of an isolator cleaning tool should also be considered to allow efficient cleaning of hard-to reach areas and guarantee an equal pressure distribution of your cleaning material (wipes/pads) on the isolator surface. The applied pressure is a determining factor in the physical removal of contaminants from a surface.
Source: Basics of Isolator Cleaning