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Heating Heart with Catheter Better Than Drugs for Heart Rhythm Disorder

By R&D Editors | November 12, 2008

Treating a common heart rhythm disorder by burning heart tissue with a catheter works better than drug treatments, a major international study has found.

One year after undergoing a treatment called catheter ablation, 75 percent of patients with an irregular heartbeat called atrial fibrillation were free of symptoms. By comparison, only 21 percent of those treated with drugs were symptom-free. Results were so convincing the trial was halted early.

The ablation group also scored higher on a quality-of-life scale.

The study included 159 patients at 19 centers, including 15 centers in the United States. Results were presented at the American Heart Association 2008 Scientific Sessions in New Orleans by lead researcher Dr. David Wilber, director of the Cardiovascular Institute at Loyola University Stritch School of Medicine in Maywood, Il.

Atrial fibrillation, often called A-Fib, is the most common form of irregular heartbeat. Electrical signals, which regulate the heartbeat, become erratic. Instead of beating regularly, the upper chambers of the heart quiver. Not all the blood gets pumped out, so clots can form. Atrial fibrillation can lead to strokes and heart failure.

A-Fib patient Robin Drabant, 34, of Hanover Park, Il., said the condition once ‘made me feel like I was 90 years old with a failing heart.’ She was on a maximum dose of an A-Fib medication, which caused fatigue. Despite the drug, she still had episodes almost every day, lasting from 10 seconds to an hour or longer. ‘I would lose my breath and could feel my heart racing and fluttering,’ she said.

Wilber performed a catheter ablation on Drabant last May, and she no longer has A-Fib episodes. ‘I had great results,’ she said.

A-Fib symptoms include heart palpitations, dizziness, fatigue, shortness of breath and fainting. ‘A lot of people are disabled,’ Wilber said. ‘They have no energy. They can’t work. They have a very poor quality of life.’

Drugs such as beta blockers and calcium channel blockers can slow the heart rate during an A-Fib episode. Other drugs such as flecainide and propafenone can help maintain a normal rhythm. When drugs don’t work or produce unacceptable side effects, alternative treatments include a pacemaker, surgery and catheter ablation.

In the ablation procedure, an electro-physiologist destroys small areas of heart tissue that are responsible for the erratic electrical signals. A catheter (thin flexible tube) is guided through blood vessels to the heart. The tip of the catheter delivers radiofrequency energy that heats and destroys tissue. Possible adverse effects include irritation of the lining of the heart, fluid in the lungs or around the heart, bleeding, clots and stroke.

In the study, 103 patients with frequent episodes of atrial fibrillation were randomly assigned to undergo ablation and 56 similar patients were randomly assigned to receive drug therapy. All patients had experienced at least three episodes of atrial fibrillation during the previous six months and had failed at least one attempt to control the rhythm with drugs.

Release Date: November 11, 2008
Source: Loyola University Health System

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