Research & Development World

  • R&D World Home
  • Topics
    • Aerospace
    • Automotive
    • Biotech
    • Careers
    • Chemistry
    • Environment
    • Energy
    • Life Science
    • Material Science
    • R&D Management
    • Physics
  • Technology
    • 3D Printing
    • A.I./Robotics
    • Software
    • Battery Technology
    • Controlled Environments
      • Cleanrooms
      • Graphene
      • Lasers
      • Regulations/Standards
      • Sensors
    • Imaging
    • Nanotechnology
    • Scientific Computing
      • Big Data
      • HPC/Supercomputing
      • Informatics
      • Security
    • Semiconductors
  • R&D Market Pulse
  • R&D 100
    • Call for Nominations: The 2025 R&D 100 Awards
    • R&D 100 Awards Event
    • R&D 100 Submissions
    • Winner Archive
    • Explore the 2024 R&D 100 award winners and finalists
  • Resources
    • Research Reports
    • Digital Issues
    • R&D Index
    • Subscribe
    • Video
    • Webinars
  • Global Funding Forecast
  • Top Labs
  • Advertise
  • SUBSCRIBE

Nanofiber Mesh Wraps Around Nerves to Aid Regeneration

By National Institute for Materials Science | February 28, 2017

Conceptual diagram showing a nanofiber mesh incorporating vitamin B12 and its application to treat a peripheral nerve injury.

A National Institute for Materials Science-Osaka University joint research team has developed a mesh which can be wrapped around injured peripheral nerves to facilitate their regeneration and restore their functions.

The team — consisting of Mitsuhiro Ebara, MANA associate principal investigator, Mechanobiology Group, NIMS, and Hiroyuki Tanaka, assistant professor, Orthopaedic Surgery, Osaka University Graduate School of Medicine — created a mesh that incorporates vitamin B12, a substance vital to the normal functioning of nervous systems, which is very soft and degrades in the body. When the mesh was applied to injured sciatic nerves in rats, it promoted nerve regeneration and recovery of their motor and sensory functions. The team is currently considering clinical application of the mesh to treat peripheral nerve disorders such as carpal tunnel syndrome (CTS).

Artificial nerve conduits have been developed in the past to treat peripheral nerve injuries, but they merely form a cross-link to the injury site and do not promote faster nerve regeneration. Moreover, their application is limited to relatively few patients suffering from a complete loss of nerve continuity. Vitamin B12 has been known to facilitate nerve regeneration, but oral administration of it has not proven to be very effective, and no devices capable of delivering vitamin B12 directly to affected sites had been available. Therefore, it had been hoped to develop such medical devices to actively promote nerve regeneration in the many patients who suffer from nerve injuries but have not lost nerve continuity.

The NIMS-Osaka University joint research team recently developed a special mesh that can be wrapped around an injured nerve which releases vitamin B12 (methylcobalamin) until the injury heals. By developing very fine mesh fibers (several hundred nanometers in diameter) and reducing the crystallinity of the fibers, the team successfully created a very soft mesh that can be wrapped around a nerve. This mesh is made of a biodegradable plastic which, when implanted in animals, is eventually eliminated from the body. In fact, experiments demonstrated that application of the mesh directly to injured sciatic nerves in rats resulted in regeneration of axons and recovery of motor and sensory functions within six weeks.

The team is currently negotiating with a pharmaceutical company and other organizations to jointly study clinical application of the mesh as a medical device to treat peripheral nerve disorders, such as CTS.

This study was supported by the JSPS KAKENHI program (Grant Number JP15K10405) and AMED’s Project for Japan Translational and Clinical Research Core Centers (also known as Translational Research Network Program).

This research was published online in the April 2017 issue of Acta Biomaterialia.

Source: National Institute for Materials Science

Related Articles Read More >

Open-source Boltz-2 can speed binding-affinity predictions 1,000-fold
Thermo Fisher’s new Orbitrap Excedion Pro targets complex biotherapeutics for drug development
FDA’s new ‘Elsa’ AI set to expedite clinical protocol reviews
Waters touts six-fold robustness with new Xevo TQ Absolute XR
rd newsletter
EXPAND YOUR KNOWLEDGE AND STAY CONNECTED
Get the latest info on technologies, trends, and strategies in Research & Development.
RD 25 Power Index

R&D World Digital Issues

Fall 2024 issue

Browse the most current issue of R&D World and back issues in an easy to use high quality format. Clip, share and download with the leading R&D magazine today.

Research & Development World
  • Subscribe to R&D World Magazine
  • Enews Sign Up
  • Contact Us
  • About Us
  • Drug Discovery & Development
  • Pharmaceutical Processing
  • Global Funding Forecast

Copyright © 2025 WTWH Media LLC. All Rights Reserved. The material on this site may not be reproduced, distributed, transmitted, cached or otherwise used, except with the prior written permission of WTWH Media
Privacy Policy | Advertising | About Us

Search R&D World

  • R&D World Home
  • Topics
    • Aerospace
    • Automotive
    • Biotech
    • Careers
    • Chemistry
    • Environment
    • Energy
    • Life Science
    • Material Science
    • R&D Management
    • Physics
  • Technology
    • 3D Printing
    • A.I./Robotics
    • Software
    • Battery Technology
    • Controlled Environments
      • Cleanrooms
      • Graphene
      • Lasers
      • Regulations/Standards
      • Sensors
    • Imaging
    • Nanotechnology
    • Scientific Computing
      • Big Data
      • HPC/Supercomputing
      • Informatics
      • Security
    • Semiconductors
  • R&D Market Pulse
  • R&D 100
    • Call for Nominations: The 2025 R&D 100 Awards
    • R&D 100 Awards Event
    • R&D 100 Submissions
    • Winner Archive
    • Explore the 2024 R&D 100 award winners and finalists
  • Resources
    • Research Reports
    • Digital Issues
    • R&D Index
    • Subscribe
    • Video
    • Webinars
  • Global Funding Forecast
  • Top Labs
  • Advertise
  • SUBSCRIBE