Research & Development World

  • R&D World Home
  • Topics
    • Aerospace
    • Automotive
    • Biotech
    • Careers
    • Chemistry
    • Environment
    • Energy
    • Life Science
    • Material Science
    • R&D Management
    • Physics
  • Technology
    • 3D Printing
    • A.I./Robotics
    • Software
    • Battery Technology
    • Controlled Environments
      • Cleanrooms
      • Graphene
      • Lasers
      • Regulations/Standards
      • Sensors
    • Imaging
    • Nanotechnology
    • Scientific Computing
      • Big Data
      • HPC/Supercomputing
      • Informatics
      • Security
    • Semiconductors
  • R&D Market Pulse
  • R&D 100
    • Call for Nominations: The 2025 R&D 100 Awards
    • R&D 100 Awards Event
    • R&D 100 Submissions
    • Winner Archive
    • Explore the 2024 R&D 100 award winners and finalists
  • Resources
    • Research Reports
    • Digital Issues
    • R&D Index
    • Subscribe
    • Video
    • Webinars
  • Global Funding Forecast
  • Top Labs
  • Advertise
  • SUBSCRIBE

Oligonucleotide Synthesis

By R&D Editors | June 21, 2012

Link Technologies Ltd., an ISO 9001:2008 certified specialist oligonucleotide reagent manufacturer, has launched two modified phosphoramidite ranges to complement its existing extensive portfolio of products to support oligonucleotide synthesis. For triplex, antisense and gene targeting studies, the RNA-type phosphoramidites provide nuclease resistance and stability, while the new ethyl phosphoramidites improve oligonucleotide stability and delivery into cells, making them ideal for therapeutic applications.

Building on from the existing range of standard nucleobase RNA phosphoramidites and CPG supports, the modified RNA-type phosphoramidites comprise two 2’-OMe RNA products, 2’-OMe-I and 2’-OMe-T. Oligonucleotides containing these modifications are ideal for triplex, antisense and gene targeting studies, as they form more stable hybrids with complementary RNA strands compared to equivalent DNA or RNA strands. Furthermore, when used in gene targeting studies, the addition of 2’-OMe residues into triplex forming oligonucleotides (TFO’s), confers the same nuclease resistance and stability as seen with duplexes.

Oligonucleotides synthesised from Link’s new ethyl phosphoramidites (available with standard nucleobase protection) have a neutral charge and slightly lipophilic character, which improves their delivery into the cell. Perfect for use in therapeutic applications, oligonucleotides containing these ethyl groups are nuclease resistant and have been shown to inhibit protein expression and cell growth when taken up by liposomes.

The new modified phosphoramidites provide increased nuclease resistance and stability, extending the experimental capabilities available.

Link Technologies Ltd

Related Articles Read More >

2025 R&D layoffs tracker: 83,543 and counting
Health-related innovation in Morocco highlighted by resident inventor patenting activity
ARPA-H funds $29M Ginkgo-led project to reshore pharma supply chains using wheat germ tech
DNA microscope offers new 3D view of organisms from the inside out
rd newsletter
EXPAND YOUR KNOWLEDGE AND STAY CONNECTED
Get the latest info on technologies, trends, and strategies in Research & Development.
RD 25 Power Index

R&D World Digital Issues

Fall 2024 issue

Browse the most current issue of R&D World and back issues in an easy to use high quality format. Clip, share and download with the leading R&D magazine today.

Research & Development World
  • Subscribe to R&D World Magazine
  • Enews Sign Up
  • Contact Us
  • About Us
  • Drug Discovery & Development
  • Pharmaceutical Processing
  • Global Funding Forecast

Copyright © 2025 WTWH Media LLC. All Rights Reserved. The material on this site may not be reproduced, distributed, transmitted, cached or otherwise used, except with the prior written permission of WTWH Media
Privacy Policy | Advertising | About Us

Search R&D World

  • R&D World Home
  • Topics
    • Aerospace
    • Automotive
    • Biotech
    • Careers
    • Chemistry
    • Environment
    • Energy
    • Life Science
    • Material Science
    • R&D Management
    • Physics
  • Technology
    • 3D Printing
    • A.I./Robotics
    • Software
    • Battery Technology
    • Controlled Environments
      • Cleanrooms
      • Graphene
      • Lasers
      • Regulations/Standards
      • Sensors
    • Imaging
    • Nanotechnology
    • Scientific Computing
      • Big Data
      • HPC/Supercomputing
      • Informatics
      • Security
    • Semiconductors
  • R&D Market Pulse
  • R&D 100
    • Call for Nominations: The 2025 R&D 100 Awards
    • R&D 100 Awards Event
    • R&D 100 Submissions
    • Winner Archive
    • Explore the 2024 R&D 100 award winners and finalists
  • Resources
    • Research Reports
    • Digital Issues
    • R&D Index
    • Subscribe
    • Video
    • Webinars
  • Global Funding Forecast
  • Top Labs
  • Advertise
  • SUBSCRIBE