Southwest Research Institute and The University of Texas at San Antonio are collaborating to create a computer model of the tubular structures in the human heart as part of a larger effort to develop a new, potentially life-saving heart surgery. These structures, called the trabeculae carneae, are poorly understood and most models of the heart ignore them.
Southwest Research Institute and The University of Texas at San Antonio are collaborating to create a computer model of the intricate structures of the human heart as part of a larger effort to develop a new, potentially life-saving heart surgery. The work, led by Dr. Keith Bartels of SwRI’s Mechanical Engineering Division and Dr. Hai-Chao Han of UTSA’s College of Engineering, is supported by a $125,000 grant from the Connecting through Research Partnerships (Connect) Program.
Within the human heart are numerous small muscle bundles called the trabeculae carneae. Despite their significance to the heart’s anatomy, their function is not well understood, and most models of the heart ignore them.
As people grow older, heart muscles can grow stiff, reducing efficiency and sometimes resulting in untreatable diastolic heart failure. SwRI and UTSA are scanning cadaver hearts using a powerful computer tomography (CT) scanner at SwRI to inform a potential new surgical intervention.
“Capturing the intricate structures of the trabeculae carneae requires something more powerful than an MRI or standard CT scanners,” Bartels said. “We’ll utilize a micro-focus X-ray CT scanner here at SwRI to create images of explanted human hearts.”
The images of the heart’s intricate inner structures will help Han to create a realistic anatomical model of the trabeculae carneae, building on a previous model he developed for the left ventricle.
“This collaboration with SwRI is a first step toward creating a new surgical method,” Han explained. “The computer model will help to provide a much deeper understanding of the trabeculae carneae.”
The images of the heart’s intricate inner structures will help Han to create a realistic anatomical model of the trabeculae carneae. Han has also been working with cardiologist Dr. Marc Feldman at UT Health San Antonio to develop a surgical treatment for subgroups of heart failure patients. This project is a critical step for the efforts.
“I hope that this work can ultimately improve the quality of people’s lives and even save lives in the long run,” Bartels said. “Heart failure is a major problem that affects millions of people.”
SwRI’s Executive Office and UTSA’s Office of the Vice President for Research, Economic Development, and Knowledge Enterprise sponsor the Connect program, which offers grant opportunities to enhance greater scientific collaboration between the two institutions.
For more information, visit swri.org/biomedical-engineering.
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