Heart failure after a heart attack is a global epidemic leading to chronic heart failure pathology. About 6 million people in the United States and 23 million worldwide suffer from this end-stage disease that involves dysfunction of the heart, a change that clinicians call cardiac remodeling. Despite medical advances, 2 to 17 percent of patients…
Memory B Cells in the Lung may be Important for More Effective Influenza Vaccinations
Seasonal influenza vaccines are typically less than 50 percent effective, according to Centers for Disease Control and Prevention studies. Research at the University of Alabama at Birmingham, published this week in Nature Immunology, may point a path to more effective vaccines. Researchers led by Troy Randall, Ph.D., professor in the UAB Department of Medicine’s Division…
Scientists Reverse Aging-Associated Skin Wrinkles and Hair Loss in a Mouse Model
Dying Cancer Cells Make Remaining Glioblastoma Cells More Aggressive and Therapy-Resistant
Untangling Brain Neuron Dysfunction in Parkinson’s Disease and Dementia with Lewy Bodies
A decay of brain function is a hallmark of Parkinson’s disease and dementia with Lewy bodies, or DLB. Specifically, cognitive dysfunction defines DLB, and nearly eight of every 10 Parkinson’s patients develop dementia. In both of these neuro-degenerative diseases, aggregates of misfolded alpha-synuclein protein develop in brain neurons, including the hippocampus, the region of the…
Common Birth Control Shot Linked to Risk of HIV Infection
Key Factor Identified in Gene Silencing
A fertilized human egg develops into multiple tissues, organs and about 200 distinct cell types. Each cell type has the same genes, but they are expressed differently during development and in mature cells. Understanding the mechanisms that turn sets of genes on or off is a fundamental quest in biology, and one that has clinical importance in…
